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  • Featured Product
  • KD/KO Validated

CoraLite®594-conjugated PGRMC1 Monoclonal antibody

PGRMC1 Monoclonal Antibody for IF-P

Host / Isotype

Mouse / IgG1

Reactivity

human, mouse, rat, pig

Applications

IF-P

Conjugate

CoraLite®594 Fluorescent Dye

CloneNo.

1C10D11

Cat No : CL594-66372

Print datasheet

Synonyms

HPR6.6, MPR, PGRMC, PGRMC1

验证数据展示

  • IF Staining of human ovary tumor using CL594-66372

    IF Staining of human ovary tumor using CL594-66372

    Immunofluorescent analysis of (4% PFA) fixed human ovary tumor tissue using CoraLite®594 PGRMC1 antibody (CL594-66372, Clone: 1C10D11 ) at dilution of 1:200.

  • IF Staining of human ovary tumor using CL594-66372

    IF Staining of human ovary tumor using CL594-66372

    Immunofluorescent analysis of (4% PFA) fixed human ovary tumor tissue using CoraLite®594 PGRMC1 antibody (CL594-66372, Clone: 1C10D11 ) at dilution of 1:200.

经过测试的应用

Positive IF detected inhuman ovary tumor tissue
Planning an IHC experiment? We recommend our IHCeasy PGRMC1 Ready-To-Use IHC Kit. PGRMC1 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 66372-1-Ig

推荐稀释比

ApplicationDilution
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL594-66372 targets PGRMC1 in IF applications and shows reactivity with human, mouse, rat, pig samples.

Tested Applications IF-P
Tested Reactivity human, mouse, rat, pig
Immunogen PGRMC1 fusion protein Ag3643 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name progesterone receptor membrane component 1
Synonyms HPR6.6, MPR, PGRMC, PGRMC1
Calculated Molecular Weight 195 aa, 22 kDa
Observed Molecular Weight 25-27 kDa
GenBank Accession NumberBC034238
Gene Symbol PGRMC1
Gene ID (NCBI) 10857
RRIDAB_2919983
Conjugate CoraLite®594 Fluorescent Dye
Excitation/Emission Maxima Wavelengths588 nm / 604 nm
Form Liquid
Purification MethodProtein G purification
UNIPROT IDO00264
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.

背景介绍

Progesterone receptor membrane component 1 (PGRMC1) is a member of a multi-protein progesterone-binding complex. However, PGRMC1 shares homology with cytochrome b5-related proteins rather than hormone receptors (PMID: 18992768). It is a heme binding protein with biding sites for Src homology (SH2) and SH3 domain-containing proteins (PMID: 17583495). PGRMC1 is overexpressed in a variety of cancers, and thus represents an important biomarker for cancer progression and a potential target for anticancer drugs (PMID: 21730960). In nonmalignant tissues, PGRMC1 is highly expressed in the liver and kidney (PMID: 9705155; 20164297).

实验方案

Product Specific Protocols
IF protocol for CL594 PGRMC1 antibody CL594-66372Download protocol
Standard Protocols
Click here to view our Standard Protocols