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验证数据展示

  • IF Staining of human ovary tumor using CL594-66372

    IF Staining of human ovary tumor using CL594-66372

    Immunofluorescent analysis of (4% PFA) fixed human ovary tumor tissue using CoraLite®594 PGRMC1 antibody (CL594-66372, Clone: 1C10D11 ) at dilution of 1:200.

  • IF Staining of human ovary tumor using CL594-66372

    IF Staining of human ovary tumor using CL594-66372

    Immunofluorescent analysis of (4% PFA) fixed human ovary tumor tissue using CoraLite®594 PGRMC1 antibody (CL594-66372, Clone: 1C10D11 ) at dilution of 1:200.

  • Featured Product
  • KD/KO验证

CoraLite®594-conjugated PGRMC1 Monoclonal antibody

PGRMC1 Monoclonal Antibody for IF-P
Cat No. CL594-66372

产品说明书

CloneNo. 1C10D11

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse, rat, pig

应用

IF-P

别名

HPR6.6, MPR, PGRMC, PGRMC1

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite®594
规格价格库存

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经过测试的应用

Positive IF-P detected inhuman ovary tumor tissue
Planning an IHC experiment? We recommend our IHCeasy PGRMC1 Ready-To-Use IHC Kit. PGRMC1 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 66372-1-Ig

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL594-66372 targets PGRMC1 in IF-P applications and shows reactivity with human, mouse, rat, pig samples.

经测试应用 IF-P Application Description
经测试反应性 human, mouse, rat, pig
免疫原

CatNo: Ag3643

Product name: Recombinant human PGRMC1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 43-195 aa of BC034238

Sequence: YKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 progesterone receptor membrane component 1
别名 HPR6.6, MPR, PGRMC, PGRMC1
计算分子量 195 aa, 22 kDa
观测分子量 25-27 kDa
GenBank蛋白编号BC034238
基因名称 PGRMC1
Gene ID (NCBI) 10857
RRIDAB_2919983
偶联类型 CoraLite®594 Fluorescent Dye
最大激发/发射波长588 nm / 604 nm
形式Liquid
纯化方式Protein G purification
UNIPROT IDO00264
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Progesterone receptor membrane component 1 (PGRMC1) is a member of a multi-protein progesterone-binding complex. However, PGRMC1 shares homology with cytochrome b5-related proteins rather than hormone receptors (PMID: 18992768). It is a heme binding protein with biding sites for Src homology (SH2) and SH3 domain-containing proteins (PMID: 17583495). PGRMC1 is overexpressed in a variety of cancers, and thus represents an important biomarker for cancer progression and a potential target for anticancer drugs (PMID: 21730960). In nonmalignant tissues, PGRMC1 is highly expressed in the liver and kidney (PMID: 9705155; 20164297).

实验方案

Product Specific Protocols
IF protocol for CL594 PGRMC1 antibody CL594-66372Download protocol
Standard Protocols
Click here to view our Standard Protocols