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验证数据展示

  • FC experiment of MG-63 using 98405-2-RR (same clone as 98405-2-PBS)

    FC experiment of MG-63 using 98405-2-RR (same clone as 98405-2-PBS)

    1x10^6 MG-63 cells were surface stained with 0.25 ug Anti-Human PDGFR beta/CD140b Rabbit RecAb (98405-2-RR, Clone: 242711A9) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98405-2-PBS in a different storage buffer formulation.

  • FC experiment of Transfected HEK-293T using 98405-2-RR (same clone as 98405-2-PBS)

    FC experiment of Transfected HEK-293T using 98405-2-RR (same clone as 98405-2-PBS)

    1x10^6 HEK-293T cells or PDGFR beta/CD140b transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human PDGFR beta/CD140b Rabbit RecAb (98405-2-RR, Clone: 242711A9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98405-2-PBS in a different storage buffer formulation.

  • FC experiment of Transfected HEK-293T using 98405-2-RR (same clone as 98405-2-PBS)

    FC experiment of Transfected HEK-293T using 98405-2-RR (same clone as 98405-2-PBS)

    1x10^6 HEK-293T cells (left) or PDGFR beta/CD140b transfected HEK-293T cells(right) were surface stained with 0.25 ug Anti-Human PDGFRB Rabbit RecAb (98405-2-RR, Clone: 242711A9) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98405-2-PBS in a different storage buffer formulation.

Anti-Human PDGFR beta/CD140b Rabbit Recombinant Antibody, PBS Only

PDGFR beta/CD140b Uni-rAbTM Recombinant Antibody for FC
Cat No. 98405-2-PBS

产品说明书

CloneNo. 242711A9

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

PDGFRB, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, CD140B

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy PDGFRB Ready-To-Use IHC Kit. PDGFRB primary antibody included.

产品信息

98405-2-PBS targets PDGFR beta/CD140b in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 PDGFR beta/CD140b fusion protein Eg3715 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 platelet-derived growth factor receptor, beta polypeptide
别名 PDGFRB, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, CD140B
计算分子量 1106 aa, 124 kDa
GenBank蛋白编号BC032224
基因名称 PDGFR beta
Gene ID (NCBI) 5159
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP09619
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PDGFRs are receptor tyrosine kinases with an extracellular ligand-binding domain and a cytoplasmic enzymatic domain. The signaling activity of PDGFRs is tightly regulated by an autoinhibitory allosteric conformation, and requires ligand-induced receptor dimerization at the cell surface to alleviate autoinhibition and achieve physiological activity (PMID: 21664579). PDGFR beta (platelet-derived growth factor receptor- β)/CD140b is a constitutive marker expressed by ASCs in the angiogenic behavior of human retinal endothelial cells (HREs). CD140b (PDGFRβ) plays a crucial role in controlling the intrinsic proliferation (PMID: 30976657)