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Species Reactivity
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验证数据展示

  • FC experiment of rat splenocytes using 98249-1-RR

    FC experiment of rat splenocytes using 98249-1-RR

    1x10^6 rat splenocytes were surface stained with 0.25 ug Anti-Rat KLRB1/CD161 Rabbit Recombinant Antibody (98249-1-RR, Clone: 241840F3) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

  • FC experiment of rat splenocytes using 98249-1-RR

    FC experiment of rat splenocytes using 98249-1-RR

    1x10^6 rat splenocytes were surface stained with 0.25 ug Anti-Rat KLRB1/CD161 Rabbit Recombinant Antibody (98249-1-RR, Clone:241840F3)(red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

  • Affinity and Kinetic Characterization of 98249-1-RR

    Affinity and Kinetic Characterization of 98249-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98249-1-RR against Rat KLRB1/CD161 were performed. The affinity constant is 88.8 pM.

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Anti-Rat KLRB1/CD161 Rabbit Recombinant Antibody

KLRB1/CD161 Uni-rAb® Recombinant Antibody for FC
Cat No. 98249-1-RR

产品说明书

CloneNo. 241840F3

宿主/亚型

Rabbit / IgG

种属反应性

rat

应用

FC

别名

Klrb1a, Killer cell lectin-like receptor subfamily B member 1A, CD161a, CD161 antigen-like family member A, Antigen 3.2.3

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格价格库存

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经过测试的应用

Positive FC detected inrat splenocytes

推荐稀释比

应用推荐稀释比
Flow Cytometry (FC)FC : 0.25 ug per 10^6 cells in 100 μl suspension
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98249-1-RR targets KLRB1/CD161 in FC applications and shows reactivity with rat samples.

经测试应用 FC Application Description
经测试反应性 rat
免疫原

fusion protein

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 killer cell lectin-like receptor subfamily B, member 1A
别名 Klrb1a, Killer cell lectin-like receptor subfamily B member 1A, CD161a, CD161 antigen-like family member A, Antigen 3.2.3
计算分子量25 kDa
GenBank蛋白编号NM_001010964.1
基因名称 Klrb1a
Gene ID (NCBI) 362443
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP27471
储存缓冲液 PBS with 0.09% sodium azide, pH 7.3.
储存条件Store at 2 - 8°C. Stable for one year after shipment.

背景介绍

CD161, also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).

实验方案

Product Specific Protocols
FC protocol for KLRB1/CD161 antibody 98249-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols