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Host
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Species Reactivity
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Species Reactivity
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Conjugate
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Compatible Species
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验证数据展示

  • FC experiment of rat splenocytes using 98249-1-RR (same clone as 98249-1-PBS)

    FC experiment of rat splenocytes using 98249-1-RR (same clone as 98249-1-PBS)

    1x10^6 rat splenocytes were surface stained with 0.25 ug Anti-Rat KLRB1/CD161 Rabbit Recombinant Antibody (98249-1-RR, Clone: 241840F3) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98249-1-PBS in a different storage buffer formulation.

  • FC experiment of rat splenocytes using 98249-1-RR (same clone as 98249-1-PBS)

    FC experiment of rat splenocytes using 98249-1-RR (same clone as 98249-1-PBS)

    1x10^6 rat splenocytes were surface stained with 0.25 ug Anti-Rat KLRB1/CD161 Rabbit Recombinant Antibody (98249-1-RR, Clone:241840F3)(red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98249-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98249-1-RR

    Affinity and Kinetic Characterization of 98249-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98249-1-RR against Rat KLRB1/CD161 were performed. The affinity constant is 88.8 pM.

    {{ptg:ProductFeaturesInfo}}

Anti-Rat KLRB1/CD161 Rabbit Recombinant Antibody, PBS Only

KLRB1/CD161 Uni-rAb® Recombinant Antibody for FC
Cat No. 98249-1-PBS

产品说明书

CloneNo. 241840F3

宿主/亚型

Rabbit / IgG

种属反应性

rat

应用

FC

别名

Klrb1a, Killer cell lectin-like receptor subfamily B member 1A, CD161a, CD161 antigen-like family member A, Antigen 3.2.3

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98249-1-PBS targets KLRB1/CD161 in FC applications and shows reactivity with rat samples.

经测试应用 FC Application Description
经测试反应性 rat
免疫原

fusion protein

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 killer cell lectin-like receptor subfamily B, member 1A
别名 Klrb1a, Killer cell lectin-like receptor subfamily B member 1A, CD161a, CD161 antigen-like family member A, Antigen 3.2.3
计算分子量25 kDa
GenBank蛋白编号NM_001010964.1
基因名称 Klrb1a
Gene ID (NCBI) 362443
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP27471
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD161, also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).