Anti-Mouse IL-12/IL-23 p40 (C17.8)

IL-12/IL-23 p40 Monoclonal Antibody for FC (Intra)
Cat No. 65097-1-Ig

产品说明书

CloneNo. C17.8

宿主/亚型

Rat / IgG2a, kappa

种属反应性

mouse

应用

FC (Intra)

Il12b, Il-12b, IL-12 p40, Il 12p40, Il 12b

缓冲液配方:  PBS and Azide
PBS and Azide
规格: 

-/ -


经过测试的应用

Positive FC (Intra) detected inIFNγ, LPS, BFA and Monensin treated RAW 264.7 cells
Planning an IF experiment? We recommend our CoraLite® Plus 488, CoraLite®594 and CoraLite® Plus 647 conjugated versions of this antibody.

推荐稀释比

应用推荐稀释比
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

65097-1-Ig targets IL-12/IL-23 p40 in FC (Intra) applications and shows reactivity with mouse samples.

经测试应用 FC (Intra) Application Description
经测试反应性 mouse
免疫原 CHO expressed, recombinant mouse IL-12 p70 种属同源性预测
宿主/亚型 Rat / IgG2a, kappa
抗体类别 Monoclonal
产品类型 Antibody
全称 interleukin 12b
别名 Il12b, Il-12b, IL-12 p40, Il 12p40, Il 12b
GenBank蛋白编号BC103608
基因名称 Il12b
Gene ID (NCBI) 16160
RRIDAB_2918399
偶联类型 Unconjugated
形式 Liquid
纯化方式Affinity purification
UNIPROT IDP43432
储存缓冲液 PBS with 0.09% sodium azide , pH 7.3
储存条件Store at 2-8°C. Stable for one year after shipment.

背景介绍

Interleukin (IL)-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).

实验方案

Product Specific Protocols
FC protocol for IL-12/IL-23 p40 antibody 65097-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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