Anti-Human IGF1R/CD221 Rabbit Recombinant Antibody, PBS Only

IGF1R/CD221 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98144-1-PBS

产品说明书

CloneNo. 241679A6

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

IGF 1 receptor, IGF1R, IGF-I receptor, IGFIR, IGFR

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy IGF1R Ready-To-Use IHC Kit. IGF1R primary antibody included.

产品信息

98144-1-PBS targets IGF1R/CD221 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 IGF I receptor
别名 IGF 1 receptor, IGF1R, IGF-I receptor, IGFIR, IGFR
计算分子量 1367 aa, 155 kDa
GenBank蛋白编号BC113612
基因名称 IGF1R
Gene ID (NCBI) 3480
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP08069
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of INS-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and INS with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cells. IGF1R is a heterotetrameric receptor, composed of two alpha subunits (130 kDa each) and two beta subunits (~98 kDa each) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds.

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