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验证数据展示

  • IF Staining of HepG2 using CL488-81135-3

    IF Staining of HepG2 using CL488-81135-3

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using CoraLite® Plus 488 IFITM3 antibody (CL488-81135-3, Clone: 242056C9 ) at dilution of 1:200, CL594-Phalloidin (red).

  • IF Staining of HepG2 using CL488-81135-3

    IF Staining of HepG2 using CL488-81135-3

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using CoraLite® Plus 488 IFITM3 antibody (CL488-81135-3, Clone: 242056C9 ) at dilution of 1:200.

CoraLite® Plus 488-conjugated IFITM3 Recombinant antibody

IFITM3 Recombinant Antibody for IF/ICC
Cat No. CL488-81135-3

产品说明书

CloneNo. 242056C9

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IF/ICC

别名

1 8U, 242056C9, DSPA2b, IFITM2/3, Interferon-induced transmembrane protein 3

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite® Plus 488
规格价格库存

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经过测试的应用

Positive IF/ICC detected inHepG2 cells
Planning an IHC experiment? We recommend our IHCeasy IFITM2/3 Ready-To-Use IHC Kit. IFITM2/3 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 81135-3-PBS

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-81135-3 targets IFITM3 in IF/ICC applications and shows reactivity with human samples.

经测试应用 IF/ICC Application Description
经测试反应性 human
免疫原 IFITM3 fusion protein Ag2285 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interferon induced transmembrane protein 3 (1-8U)
别名 1 8U, 242056C9, DSPA2b, IFITM2/3, Interferon-induced transmembrane protein 3
计算分子量 133 aa, 15 kDa
观测分子量15-20 kDa
GenBank蛋白编号BC006794
基因名称 IFITM3
Gene ID (NCBI) 10410
偶联类型 CoraLite® Plus 488 Fluorescent Dye
最大激发/发射波长493 nm / 522 nm
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ01628
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

IFITM3, also named as interferon-inducible protein 1-8U, belongs to the CD225 family. It is IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus, by inhibiting the early steps of replication. IFITM3 is identified as interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. IFITM3, the most potent antiviral IFITM, was found to inhibit an uncharacterized early infectious event after VSV endocytosis, but before primary transcription of its viral genome. IFITM proteins are viral restriction factors that can inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. They differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression.

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 IFITM3 antibody CL488-81135-3Download protocol
Standard Protocols
Click here to view our Standard Protocols