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验证数据展示

  • FC experiment of human peripheral blood leukocytes using 98412-2-RR (same clone as 98412-2-PBS)

    FC experiment of human peripheral blood leukocytes using 98412-2-RR (same clone as 98412-2-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human DcR2 Rabbit RecAb (98412-2-RR, Clone: 242916D5) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98412-2-PBS in a different storage buffer formulation.

  • FC experiment of human peripheral blood leukocytes using 98412-2-RR (same clone as 98412-2-PBS)

    FC experiment of human peripheral blood leukocytes using 98412-2-RR (same clone as 98412-2-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human DcR2 Rabbit RecAb (98412-2-RR, Clone: 242916D5) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98412-2-PBS in a different storage buffer formulation.

Anti-Human DcR2 Rabbit Recombinant Antibody, PBS Only

DcR2 Uni-rAb® Recombinant Antibody for FC
Cat No. 98412-2-PBS

产品说明书

CloneNo. 242916D5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

CD264, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL R4

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98412-2-PBS targets DcR2 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原

CatNo: Eg3487

Product name: Recombinant Human DcR2 protein (rFc Tag)

Source: mammalian cells-derived, pHZ-KIsec-C-rFc

Tag: C-rFc

Domain: 56-211 aa of NM_003840.5

Sequence: ATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYH

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
别名 CD264, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL R4
计算分子量42 kDa
GenBank蛋白编号NM_003840.5
基因名称 DcR2
Gene ID (NCBI) 8793
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ9UBN6
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Decoy receptor 2 (DcR2) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It functions as a decoy receptor for TNF-related apoptosis-inducing ligand (TRAIL), thereby inhibiting TRAIL-mediated apoptosis (PMID: 15538968; 9537512). It has been considered a tentative marker of cellular senescence (PMID: 16079833; 22751116). Additionally, DCR2 has been implicated in the regulation of renal fibrosis and cell senescence, contributing to the pathogenesis of diabetic nephropathy (PMID: 35661704).

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