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验证数据展示

  • FC experiment of mouse splenocytes using 98246-2-RR (same clone as 98246-2-PBS)

    FC experiment of mouse splenocytes using 98246-2-RR (same clone as 98246-2-PBS)

    1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse BTLA/CD272 Rabbit Recombinant Antibody (98246-2-RR, Clone: 242133A1) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Mouse CD45R (B220) (RA3-6B2) (APC-65139, Clone: RA3-6B2). Cells were not fixed. This data was developed using the same antibody clone with 98246-2-PBS in a different storage buffer formulation.

  • FC experiment of mouse splenocytes using 98246-2-RR (same clone as 98246-2-PBS)

    FC experiment of mouse splenocytes using 98246-2-RR (same clone as 98246-2-PBS)

    1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse BTLA/CD272 Rabbit Recombinant Antibody (98246-2-RR, Clone: 242133A1)(red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98246-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98246-2-RR

    Affinity and Kinetic Characterization of 98246-2-RR

    Biolayer interferometry (BLl) kinetic assays of 98246-2-RR against Mouse BTLA/CD272 were performed. The affinity constant is 0.441 nM.

Anti-Mouse BTLA/CD272 Rabbit Recombinant Antibody, PBS Only

BTLA/CD272 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98246-2-PBS

产品说明书

CloneNo. 242133A1

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC

别名

CD272, Btla, B- and T-lymphocyte-associated protein, B- and T-lymphocyte attenuator, 242133A1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98246-2-PBS targets BTLA/CD272 in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
经测试反应性 mouse
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 B and T lymphocyte associated
别名 CD272, Btla, B- and T-lymphocyte-associated protein, B- and T-lymphocyte attenuator, 242133A1
计算分子量34kDa
GenBank蛋白编号AAI08964.1
基因名称 Btla
Gene ID (NCBI) 208154
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ32MV9
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

BTLA, also known as CD272, is a member of the CD28 superfamily and is a type I membrane glycoprotein identified as an inhibitory receptor (PMID: 33859648). BTLA is extensively expressed in lymph nodes, thymus, and spleen, with little or no expression in organs such as the heart, kidney, brain, and liver (PMID: 33859648). Among immune cells, BTLA is primarily expressed in B and T cells, with higher expression in B cells compared to T cells in the mouse spleen (PMID: 33859648). BTLA plays a crucial role in regulating stimulatory and inhibitory signals in immune responses.