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验证数据展示

  • FC experiment of human PBMCs using 98112-1-RR (same clone as 98112-1-PBS)

    FC experiment of human PBMCs using 98112-1-RR (same clone as 98112-1-PBS)

    1x10^6 unstimulated or Con-A-stimulated human PBMCs were surface stained with 0.25 ug Anti-Human TNFRSF9/CD137 Rabbit RecAb (98112-1-RR, Clone:241344F3), or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Human CD8. Cells were not fixed. This data was developed using the same antibody clone with 98112-1-PBS in a different storage buffer formulation.

  • IF Staining of human tonsillitis using 98112-1-RR (same clone as 98112-1-PBS)

    IF Staining of human tonsillitis using 98112-1-RR (same clone as 98112-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded human tonsillitis tissue using TNFRSF9/CD137 antibody (98112-1-RR, Clone: 241344F3 ) at dilution of 1:180 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 98112-1-PBS in a different storage buffer formulation.

  • IF Staining of human tonsillitis using 98112-1-RR (same clone as 98112-1-PBS)

    IF Staining of human tonsillitis using 98112-1-RR (same clone as 98112-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded human tonsillitis tissue using TNFRSF9/CD137 antibody (98112-1-RR, Clone: 241344F3 ) at dilution of 1:180 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 98112-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 98112-1-RR (same clone as 98112-1-PBS)

    IHC staining of human tonsillitis using 98112-1-RR (same clone as 98112-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 98112-1-RR (TNFRSF9/CD137 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 98112-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 98112-1-RR (same clone as 98112-1-PBS)

    IHC staining of human tonsillitis using 98112-1-RR (same clone as 98112-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 98112-1-RR (TNFRSF9/CD137 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 98112-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98112-1-RR

    Affinity and Kinetic Characterization of 98112-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98112-1-RR against Human TNFRSF9/CD137 were performed. The affinity constant is 10.3 nM.

Anti-Human TNFRSF9/CD137 Rabbit Recombinant Antibody, PBS Only

TNFRSF9/CD137 Uni-rAb® Recombinant Antibody for IHC, IF-P, FC
Cat No. 98112-1-PBS

产品说明书

CloneNo. 241344F3

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, IF-P, FC

别名

TNFRSF9, 241344F3, 4 1BB, 4 1BB ligand receptor, 4-1BB ligand receptor

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98112-1-PBS targets TNFRSF9/CD137 in IHC, IF-P, FC applications and shows reactivity with human samples.

经测试应用 IHC, IF-P, FC Application Description
经测试反应性 human
免疫原

Recombinant Protein

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tumor necrosis factor receptor superfamily, member 9
别名 TNFRSF9, 241344F3, 4 1BB, 4 1BB ligand receptor, 4-1BB ligand receptor
计算分子量 28 kDa
GenBank蛋白编号BC006196
基因名称 TNFRSF9/CD137
Gene ID (NCBI) 3604
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ07011
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD137, also known as TNFRSF9 or 4-1BB, is an inducible T cell surface receptor that belongs to the tumor necrosis factor receptor superfamily. CD137 is a transmembrane protein expressed on the surface of activated T-cells. In addition, activation-dependent expression of CD137 has also been found in B lymphocytes, monocytes, and diverse nonlymphoid cell types. CD137 provides a co-stimulatory signal that enhances the survival, and differentiation of cells, and has a crucial role in the development of CD8 cytotoxic T cells and anti-tumor immunity. (PMID: 9826581; 23696891)

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