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验证数据展示

  • WB analysis using 86138-1-RR (same clone as 86138-1-PBS)

    WB analysis using 86138-1-RR (same clone as 86138-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86138-1-RR (SPINT1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86138-1-PBS in a different storage buffer formulation.

  • WB analysis of MCF-7 using 86138-1-RR (same clone as 86138-1-PBS)

    WB analysis of MCF-7 using 86138-1-RR (same clone as 86138-1-PBS)

    MCF-7 cells were subjected to SDS PAGE followed by western blot with 86138-1-RR (SPINT1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86138-1-PBS in a different storage buffer formulation.

  • WB analysis using 86138-1-RR (same clone as 86138-1-PBS)

    WB analysis using 86138-1-RR (same clone as 86138-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86138-1-RR (SPINT1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86138-1-PBS in a different storage buffer formulation.

SPINT1/HAI-1 Recombinant monoclonal antibody, PBS Only

SPINT1/HAI-1 Uni-rAb® Recombinant Antibody for WB, Indirect ELISA
Cat No. 86138-1-PBS

产品说明书

CloneNo. 250560F1

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, Indirect ELISA

别名

HAI 1, HAI-1, SPINT1, HAI, HAI1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86138-1-PBS targets SPINT1/HAI-1 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Eg3131

Product name: Recombinant Human SPINT1 protein (rFc Tag) (HPLC verified)

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 35-465 aa of NM_181642.2

Sequence: AGPPPAPPGLPAGADCLNSFTAGVPGFVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLINCLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLVLKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTVLSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 serine peptidase inhibitor, Kunitz type 1
别名 HAI 1, HAI-1, SPINT1, HAI, HAI1
计算分子量58 kDa
观测分子量58-70 kDa
GenBank蛋白编号NM_181642.2
基因名称 HAI-1
Gene ID (NCBI) 6692
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDO43278-1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is also named as SPINT1 and Kunitz-type protease inhibitor 1. HAI-1 is critical to control matriptase proteolytic activity (PMID: 25310042). HAI-1 inhibits matriptase activity through forming complex with activated matriptase (PMID: 30370662). matriptase, HAI‐1 also binds to and inhibits a variety of serine proteases including of hepsin, plasmin, prostasin, TMPRSS13 and HAT. HAI-1 as a cell-autonomous tumor suppressor that negatively regulates the HGF pathway (PMID: 25925948). HAI-1 is inhibitor of HGFAC (PMID: 9045658). HAI-1 inhibits serine protease activity of ST14/matriptase in vitro (PMID: 28710277). HAI-1 inhibits serine protease activity of TMPRSS13, via the BPTI/Kunitz inhibitor 1 domain (PMID: 20977675). HAI-1 expression is reduced in many cancer types, which is implicated in the progression of cancer and is associated with a worse prognosis in cancer patients (PMID: 30370662).

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