验证数据展示
产品信息
19815-1-PBS targets SPG21 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag13851 Product name: Recombinant human SPG21 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-308 aa of BC000244 Sequence: MGEIKVSPDYNWFRGTVPLKKIIVDDDDSKIWSLYDAGPRSIRCPLIFLPPVSGTADVFFRQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDKVHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNSFSDTSIFNQTWTANSFWLMPAFMLKKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIPVTIMDVFDQSALSTEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQFHGTKYAAIDPSMVSAEELEVQKGSLGISQEEQ 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | spastic paraplegia 21 (autosomal recessive, Mast syndrome) |
| 别名 | ABHD21, Acid cluster protein 33, ACP33, BM 019, GL010 |
| 计算分子量 | 308 aa, 35 kDa |
| 观测分子量 | 35 kDa |
| GenBank蛋白编号 | BC000244 |
| 基因名称 | SPG21 |
| Gene ID (NCBI) | 51324 |
| RRID | AB_3741970 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9NZD8 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
SPG21, also known as Maspardin, is a protein encoded by the SPG21 gene on human chromosome 15q22.31. SPG21 is critical for the proper movement and positioning of lysosomes within neurons, which is essential for maintaining axonal health. Mutations in the SPG21 gene underlie hereditary spastic paraplegia (SPG) type 21 (also known as Mast syndrome). This is a complex form of SPG characterized by motor coordination defects due to axonal degeneration of corticospinal neurons and associated with dementia, cerebellar, and extrapyramidal abnormalities and, in some cases, seizures.(PMID: 41400694,PMID: 34492745)
