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验证数据展示

  • WB analysis using 17640-1-AP (same clone as 17640-1-PBS)

    WB analysis using 17640-1-AP (same clone as 17640-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 17640-1-AP (SPCS3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17640-1-PBS in a different storage buffer formulation.

  • WB analysis using 17640-1-AP (same clone as 17640-1-PBS)

    WB analysis using 17640-1-AP (same clone as 17640-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 17640-1-AP (SPCS3 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17640-1-PBS in a different storage buffer formulation.

  • IHC staining of rat liver using 17640-1-AP (same clone as 17640-1-PBS)

    IHC staining of rat liver using 17640-1-AP (same clone as 17640-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat liver tissue slide using 17640-1-AP (SPCS3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17640-1-PBS in a different storage buffer formulation.

  • IHC staining of human placenta using 17640-1-AP (same clone as 17640-1-PBS)

    IHC staining of human placenta using 17640-1-AP (same clone as 17640-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 17640-1-AP (SPCS3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17640-1-PBS in a different storage buffer formulation.

SPCS3 Polyclonal antibody, PBS Only

SPCS3 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 17640-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

PRO3567, SPase 22/23 kDa subunit, SPC22, SPC22/23, SPC3

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

17640-1-PBS targets SPCS3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag11780

Product name: Recombinant human SPCS3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-180 aa of BC047290

Sequence: MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 signal peptidase complex subunit 3 homolog (S. cerevisiae)
别名 PRO3567, SPase 22/23 kDa subunit, SPC22, SPC22/23, SPC3
计算分子量 180 aa, 20 kDa
观测分子量23 kDa
GenBank蛋白编号BC047290
基因名称 SPCS3
Gene ID (NCBI) 60559
RRIDAB_3669279
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP61009
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The microsomal signal peptidase complex (SPC), which is an essential membrane component in the endoplasmic reticulum (ER), has five subunits, including SEC11A, SEC11C, SPCS1, SPCS2, and SPCS3. Functionally, SPC removes signal peptides (SPs) from a series of secretory pre-proteins with high specificity. The dysregulation of the other SPC subunits was also observed in some tumors. SPCS3 expression can be used as a component of a risk score model to predict the survival of patients with pancreatic adenocarcinoma. (PMID: 35653344)

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