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验证数据展示

  • WB analysis using 87882-1-RR

    WB analysis using 87882-1-RR

    Various lysates were subjected to SDS PAGE followed by western blot with 87882-1-RR (SORL antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

  • IF Staining of mouse brain using 87882-1-RR

    IF Staining of mouse brain using 87882-1-RR

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse brain tissue using SORLA antibody (87882-1-RR, Clone: 253502E4 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Affinity of 87882-1-RR

    Affinity of 87882-1-RR

    Biolayer interferometry (BLI) kinetic assays of 87882-1-RR against Human SORLA were performed. The affinity constant is 2.06 nM.

SORLA Recombinant monoclonal antibody

SORLA Uni-rAb® Recombinant Antibody for WB, IF-P, ELISA
Cat No. 87882-1-RR

产品说明书

CloneNo. 253502E4

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF-P, ELISA

别名

SORL1, C11orf32, LDLR relative with 11 ligand-binding repeats, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, SORL 1

缓冲液配方:  PBS, Azide, Glycerol
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
Unconjugated
规格价格库存

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经过测试的应用

Positive WB detected inmouse brain tissue, rat brain tissue
Positive IF-P detected inmouse brain tissue
Planning an IHC experiment? We recommend our IHCeasy SORL1 Ready-To-Use IHC Kit. SORL1 primary antibody included.

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:2000-1:10000
Immunofluorescence (IF)-PIF-P : 1:200-1:800
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

87882-1-RR targets SORLA in WB, IF-P, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF-P, ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Eg5593

Product name: Recombinant human SORL protein

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 82-181 aa of NM_003105.6

Sequence: SAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFAD

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 sortilin-related receptor, L(DLR class) A repeats-containing
别名 SORL1, C11orf32, LDLR relative with 11 ligand-binding repeats, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, SORL 1
计算分子量248 kDa
观测分子量 300-310 kDa
GenBank蛋白编号NM_003105.6
基因名称 SORLA
Gene ID (NCBI) 6653
RRIDAB_3745807
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ92673
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

SorLA also known as SorL1 or LR11, is a multiligand receptor belonging to the LDL receptor superfamily. It is also a member of vacuolar protein sorting-10 (Vps10) family and is enriched in the brain. SorLA acts as an sorting receptor for APP and prevents amyloidogenic processing of APP. Downregulation of SorLA has been found in patients with sporadic Alzheimer disease (AD). Currently SorLA has emerged as a potential target for AD therapy. (25404298)

实验方案

Product Specific Protocols
IF protocol for SORLA antibody 87882-1-RRDownload protocol
WB protocol for SORLA antibody 87882-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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