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验证数据展示

  • WB analysis using 87882-1-RR (same clone as 87882-1-PBS)

    WB analysis using 87882-1-RR (same clone as 87882-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87882-1-RR (SORL antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87882-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 87882-1-RR (same clone as 87882-1-PBS)

    IF Staining of mouse brain using 87882-1-RR (same clone as 87882-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse brain tissue using SORLA antibody (87882-1-RR, Clone: 253502E4 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 87882-1-PBS in a different storage buffer formulation.

  • Affinity of 87882-1-RR

    Affinity of 87882-1-RR

    Biolayer interferometry (BLI) kinetic assays of 87882-1-RR against Human SORLA were performed. The affinity constant is 2.06 nM.

SORLA Recombinant monoclonal antibody, PBS Only

SORLA Uni-rAb® Recombinant Antibody for WB, IF-P, Indirect ELISA
Cat No. 87882-1-PBS

产品说明书

CloneNo. 253502E4

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF-P, Indirect ELISA

别名

SORL1, C11orf32, LDLR relative with 11 ligand-binding repeats, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, SORL 1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy SORL1 Ready-To-Use IHC Kit. SORL1 primary antibody included.

产品信息

87882-1-PBS targets SORLA in WB, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF-P, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Eg5593

Product name: Recombinant human SORL protein

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 82-181 aa of NM_003105.6

Sequence: SAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFAD

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 sortilin-related receptor, L(DLR class) A repeats-containing
别名 SORL1, C11orf32, LDLR relative with 11 ligand-binding repeats, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, SORL 1
计算分子量248 kDa
观测分子量 300-310 kDa
GenBank蛋白编号NM_003105.6
基因名称 SORLA
Gene ID (NCBI) 6653
RRIDAB_3745807
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ92673
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SorLA also known as SorL1 or LR11, is a multiligand receptor belonging to the LDL receptor superfamily. It is also a member of vacuolar protein sorting-10 (Vps10) family and is enriched in the brain. SorLA acts as an sorting receptor for APP and prevents amyloidogenic processing of APP. Downregulation of SorLA has been found in patients with sporadic Alzheimer disease (AD). Currently SorLA has emerged as a potential target for AD therapy. (25404298)

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