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验证数据展示

  • WB analysis using 12296-1-AP (same clone as 12296-1-PBS)

    WB analysis using 12296-1-AP (same clone as 12296-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12296-1-AP (SFXN1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12296-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 12296-1-AP (same clone as 12296-1-PBS)

    IHC staining of human breast cancer using 12296-1-AP (same clone as 12296-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 12296-1-AP (SFXN1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12296-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 12296-1-AP (same clone as 12296-1-PBS)

    IHC staining of human breast cancer using 12296-1-AP (same clone as 12296-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 12296-1-AP (SFXN1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12296-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 12296-1-AP (same clone as 12296-1-PBS)

    IP experiment of mouse brain using 12296-1-AP (same clone as 12296-1-PBS)

    IP result of anti-SFXN1 (IP:12296-1-AP, 4ug; Detection:12296-1-AP 1:800) with mouse brain tissue lysate 4000ug. This data was developed using the same antibody clone with 12296-1-PBS in a different storage buffer formulation.

  • WB analysis of MCF-7 using 12296-1-AP (same clone as 12296-1-PBS)

    WB analysis of MCF-7 using 12296-1-AP (same clone as 12296-1-PBS)

    WB result of SFXN1 antibody (12296-1-AP; 1:20000; incubated at room temperature for 1.5 hours) with sh-Control and sh-SFXN1 transfected MCF-7 cells. This data was developed using the same antibody clone with 12296-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

SFXN1 Polyclonal antibody, PBS Only

SFXN1 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 12296-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IP, Indirect ELISA

别名

sideroflexin 1, Sideroflexin-1, TCC, Tricarboxylate carrier protein

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

12296-1-PBS targets SFXN1 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag2985

Product name: Recombinant human SFXN1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-236 aa of BC020517

Sequence: MILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 sideroflexin 1
别名 sideroflexin 1, Sideroflexin-1, TCC, Tricarboxylate carrier protein
计算分子量35.6 kDa
观测分子量 30-35 kDa
GenBank蛋白编号BC020517
基因名称 SFXN1
Gene ID (NCBI) 94081
RRIDAB_2185814
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9H9B4
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SFXN1, the founding member of the SLC56 family, was identified by positional cloning of the mutation in the flexed-tail mouse model with sideroblastic anemia. SFXN1 was recently identified as a mitochondrial serine transporter essential for one-carbon (1C) metabolism, a process in which folate species are generated and used in biosynthetic pathways required for cell proliferation. In HEK293 cells, SFXN1 is the most abundant isoform among the SFXNs.

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