验证数据展示
产品信息
16802-1-PBS targets RNF26 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag10285 Product name: Recombinant human RNF26 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 239-433 aa of BC000058 Sequence: AVTVTVLHPDFTLRLATQALSQLHARPSYHRLREDVMRLSRLALGSEAWRRVWSRSLQLASWPNRGGAPGAPQGDPMRVFSVRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKKCVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCRRGILQTLNVYL 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | ring finger protein 26 |
| 别名 | E3 ubiquitin-protein ligase RNF26, EC:2.3.2.27, RING finger protein 26 |
| 计算分子量 | 433 aa, 48 kDa |
| 观测分子量 | 48 kDa |
| GenBank蛋白编号 | BC000058 |
| 基因名称 | RNF26 |
| Gene ID (NCBI) | 79102 |
| RRID | AB_2878317 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9BY78 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
RNF26 is concentrated predominantly in the PN segment of the ER membrane, which corresponds with its ability to position all endosomal vesicles in the PN region of the cell. RNF26 resides in the perinuclear ER membrane, and this feature enables it to spatially restrict various endolysosomal species by attracting ubiquitin-binding vesicle adaptors through a ubiquitindependent ER MCS. RNF26 is an important E3 ubiquitin ligase that has been associated with poor prognosis in bladder cancer. And RNF26 is prevalent in normal human tissues but is upregulated in several human tumor cell lines (HL-60, HeLa S3 and SW480) (PMID: 33472082, 37519262).
