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  • Featured Product
  • KD/KO Validated

RBBP6 Polyclonal antibody

RBBP6 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Conjugate

Unconjugated

Cat No : 11882-1-AP

Print datasheet

Synonyms

MY038, P2P R, P2PR, PACT, Protein P2P R, RBBP6, RBQ 1, RBQ1, SNAMA

验证数据展示

  • WB analysis using 11882-1-AP

    WB analysis using 11882-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 11882-1-AP (RBBP6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

经过测试的应用

Positive WB detected inJurkat cells, HEK-293 cells, MCF-7 cells

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

11882-1-AP targets RBBP6 in WB, ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, ELISA
Cited ApplicationsWB
Tested Reactivity human, mouse
Cited Reactivityhuman
Immunogen RBBP6 fusion protein Ag2484 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name retinoblastoma binding protein 6
Synonyms MY038, P2P R, P2PR, PACT, Protein P2P R, RBBP6, RBQ 1, RBQ1, SNAMA
Calculated Molecular Weight 1792 aa, 200 kDa
Observed Molecular Weight250 kDa
GenBank Accession NumberBC029352
Gene Symbol RBBP6
Gene ID (NCBI) 5930
RRIDAB_2177794
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ7Z6E9
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

RBBP6 (retinoblastoma binding protein 6) is a multifunctional protein that interacts with both p53 and pRb and has been implicated in mRNA processing. It has also been identified as a putative E3 ubiquitin ligase due to the presence of a RING finger domain [PMID:18851979]. RBBP6 contains an N-terminal ubiquitin-like domain and a cysteine-rich RING finger-like domain, through which it promotes the ubiquitination of p53 by Hdm2 in an E4-like manner [PMID:17470788]. It is implicated in a diverse set of cellular functions, including mRNA metabolism, regulation of the cell cycle, tumorigenesis, and development [PMID:12938151,17470788].

实验方案

Product Specific Protocols
WB protocol for RBBP6 antibody 11882-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB

Commun Biol

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

Authors - Christopher Noyes
  • KD Validated
View Article