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RAD50 Recombinant monoclonal antibody, PBS Only

RAD50 Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 84969-4-PBS

产品说明书

CloneNo. 242541A5

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

242541A5, hRad50, RAD50 homolog (S. cerevisiae)

缓冲液配方:  PBS Only
偶联物:  Unconjugated
规格价格库存


Planning an IHC experiment? We recommend our IHCeasy RAD50 Ready-To-Use IHC Kit. RAD50 primary antibody included.

产品信息

84969-4-PBS targets RAD50 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag29949

Product name: Recombinant human RAD50 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 275-425 aa of NM_005732

Sequence: LDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLK

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 RAD50 homolog (S. cerevisiae)
别名 242541A5, hRad50, RAD50 homolog (S. cerevisiae)
计算分子量 154 kDa
观测分子量 154 kDa
GenBank蛋白编号NM_005732
基因名称 RAD50
Gene ID (NCBI) 10111
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ92878
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

RAD50 belongs to the ABC-ATPase protein family that concurs in forming the Nucleotide Binding Domain (NBD). ATP binding to Rad50 induces a conformational change that dramatically increases the Rad50 NBD affinity for itself, allowing for its dimerization (PMID: 37569756). The Mre11-Rad50 (MR) complex has key functions in the detection, signaling and repair of DNA breaks (PMID: 35501303).

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