验证数据展示
产品信息
87893-2-PBS targets Phospho-STK11/LKB1 (Ser334) in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | serine/threonine kinase 11 |
| 别名 | Phospho-LKB1, Phospho-LKB1 (Ser334), Phospho-STK11, Phospho-STK11 (Ser334), Phospho-STK11/LKB1 |
| 计算分子量 | 49 kDa |
| 观测分子量 | 50-55 kDa |
| GenBank蛋白编号 | BC007981 |
| 基因名称 | LKB1 |
| Gene ID (NCBI) | 6794 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q15831 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
STK11(serine/threonine-protein kinase 11) is also named as LKB1, PJS, and belongs to the protein kinase superfamily. Phospho-STK11 (Ser334), also called p-LKB1 (S334), is an inhibitory phosphorylation modification of the tumor suppressor kinase LKB1. This site is phosphorylated by Akt and PIM kinases upon growth factor stimulation. Phosphorylated Ser334 recruits 14-3-3 proteins, sequestering LKB1 in the nucleus and disrupting its binding to STRADα-MO25 complex. This abolishes LKB1's capacity to activate AMPK, impairing energy sensing, autophagy and anti-proliferative signals. Elevated p-LKB1 (Ser334) accelerates proliferation in breast, prostate and lung cancers, weakens metabolic stress response, and correlates with poor tumor prognosis. It serves as a biomarker for aberrant PI3K/Akt oncogenic signaling and represents a target to restore LKB1 tumor-suppressive function. (PMID: 22611470, 34193159)
