验证数据展示
产品信息
80103-2-PBS targets Phospho-GRB10 (Ser476) in WB, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, FC (Intra), Indirect ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | growth factor receptor-bound protein 10 |
| 别名 | GRB10 (Ser476), p-GRB10, p-GRB10 (Ser476), p-GRB10(Ser476), p-GRB10-Ser476 |
| 计算分子量 | 536aa,61 kDa; 594aa,67 kDa |
| 观测分子量 | 70-80 kDa |
| GenBank蛋白编号 | BC024285 |
| 基因名称 | GRB10 |
| Gene ID (NCBI) | 2887 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q13322 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Growth factor receptor-bound protein 10 (GRB10) is an adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. GRB10 has three consensus domains including pleckstrin homology (PH) domain, SH2/SH3 domain and Ras-associating domain. By binding to kinases, GRB10 suppresses signals from activated receptors tyrosine kinases, including the INSR and INS-like growth factor (IGF1R) receptors. It may play a role in mediating INS-stimulated ubiquitination of INSR, leading to proteasomal degradation. It has been reported that GRB10 is a direct substrate of mechanistic/mammalian target of mTOR and can be phosphorylated at Ser150, Ser428 and Ser476 identified as MAPK-mediated phosphorylation sites. (PMID: 15952796, 24746805, 21659605)
