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验证数据展示

  • IF Staining of Jurkat using 85062-4-RR (same clone as 85062-4-PBS)

    IF Staining of Jurkat using 85062-4-RR (same clone as 85062-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed Jurkat cells using PTPN22 antibody (85062-4-RR, Clone: 242688A2 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 85062-4-PBS in a different storage buffer formulation.

  • FC experiment of Jurkat using 85062-4-RR (same clone as 85062-4-PBS)

    FC experiment of Jurkat using 85062-4-RR (same clone as 85062-4-PBS)

    1x10^6 Jurkat cells were intracellularly stained with 0.25 ug PTPN22 Recombinant antibody (85062-4-RR, Clone:242688A2) and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2)(red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 85062-4-PBS in a different storage buffer formulation.

PTPN22 Recombinant antibody, PBS Only

PTPN22 Uni-rAbTM Recombinant Antibody for IF/ICC, FC (Intra), Indirect ELISA
Cat No. 85062-4-PBS

产品说明书

CloneNo. 242688A2

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IF/ICC, FC (Intra), Indirect ELISA

别名

242688A2, EC:3.1.3.48, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, LyP, LYP1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

85062-4-PBS targets PTPN22 in IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IF/ICC, FC (Intra), Indirect ELISA Application Description
经测试反应性 human
免疫原 PTPN22 fusion protein Ag2397 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
别名 242688A2, EC:3.1.3.48, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, LyP, LYP1
计算分子量 82 kDa, 92 kDa
GenBank蛋白编号BC017785
基因名称 PTPN22
Gene ID (NCBI) 26191
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ9Y2R2
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PTPN22(Tyrosine-protein phosphatase non-receptor type 22) is also named as LyP,PEP,PTPN8.It belongs to the protein-tyrosine phosphatase family and non-receptor class 4 subfamily.It acts as negative regulator of T-cell receptor (TCR) signaling.Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE). It has some isoforms produced by alternative splicing with calculated molecular mass of 79-92 kDa, and apparent molecular mass of 100-110 kDa.