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验证数据展示

  • WB analysis using 22632-1-AP (same clone as 22632-1-PBS)

    WB analysis using 22632-1-AP (same clone as 22632-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22632-1-AP (PKP1 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22632-1-PBS in a different storage buffer formulation.

  • WB analysis using 22632-1-AP (same clone as 22632-1-PBS)

    WB analysis using 22632-1-AP (same clone as 22632-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22632-1-AP (Plakophilin 1 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22632-1-PBS in a different storage buffer formulation.

  • IHC staining of human skin cancer using 22632-1-AP (same clone as 22632-1-PBS)

    IHC staining of human skin cancer using 22632-1-AP (same clone as 22632-1-PBS)

    Immunohistochemical analysis of paraffin-embedded skin cancer slide using 22632-1-AP (PKP1 antibody) at dilution of 1:1200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22632-1-PBS in a different storage buffer formulation.

  • IF Staining of PC-3 using 22632-1-AP (same clone as 22632-1-PBS)

    IF Staining of PC-3 using 22632-1-AP (same clone as 22632-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed PC-3 cells using PKP1 antibody (22632-1-AP) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). This data was developed using the same antibody clone with 22632-1-PBS in a different storage buffer formulation.

Plakophilin 1 Polyclonal antibody, PBS Only

Plakophilin 1 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 22632-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

PKP1, B6P, Plakophilin-1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

22632-1-PBS targets Plakophilin 1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag18153

Product name: Recombinant human PKP1 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 412-726 aa of BC114571

Sequence: NLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGANSLRNFTSRF

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
别名 PKP1, B6P, Plakophilin-1
计算分子量 747 aa, 83 kDa
观测分子量70-75 kDa
GenBank蛋白编号BC114571
基因名称 PKP1
Gene ID (NCBI) 5317
RRIDAB_3085701
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ13835
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Plakophilin 1, also known as PKP1, B6P, is a member of the arm-repeat protein family. PKP1 contains arm-repeat (armadillo) domains, localizes to nuclei and cell desmosomes, and participates in linking cadherins to intermediate filaments in the cytoskeleton (PMID: 10747098). PKP1 contributes to epidermal morphogenesis and facilitates the formation of intermediate filaments. Mutations in PKP1 have been associated with the ectodermal dysplasia/skin fragility syndrome (PubMed:9326952, 10852826).

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