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验证数据展示

  • WB analysis using 12417-1-AP (same clone as 12417-1-PBS)

    WB analysis using 12417-1-AP (same clone as 12417-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12417-1-AP (OSBPL3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12417-1-PBS in a different storage buffer formulation.

  • WB analysis of HCT 116 using 12417-1-AP (same clone as 12417-1-PBS)

    WB analysis of HCT 116 using 12417-1-AP (same clone as 12417-1-PBS)

    WB result of OSBPL3 antibody (12417-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-OSBPL3 transfected HCT 116 cells. This data was developed using the same antibody clone with 12417-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 12417-1-AP (same clone as 12417-1-PBS)

    IHC staining of human colon cancer using 12417-1-AP (same clone as 12417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 12417-1-AP (OSBPL3 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12417-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with OSBPL3 antibody included
  • IHC staining of human colon cancer using 12417-1-AP (same clone as 12417-1-PBS)

    IHC staining of human colon cancer using 12417-1-AP (same clone as 12417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 12417-1-AP (OSBPL3 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12417-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with OSBPL3 antibody included
  • IHC staining of mouse kidney using 12417-1-AP (same clone as 12417-1-PBS)

    IHC staining of mouse kidney using 12417-1-AP (same clone as 12417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 12417-1-AP (OSBPL3 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12417-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with OSBPL3 antibody included
  • IHC staining of human ovary cancer using 12417-1-AP (same clone as 12417-1-PBS)

    IHC staining of human ovary cancer using 12417-1-AP (same clone as 12417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary cancer tissue slide using 12417-1-AP (OSBPL3 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12417-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with OSBPL3 antibody included
  • IHC staining of mouse bladder using 12417-1-AP (same clone as 12417-1-PBS)

    IHC staining of mouse bladder using 12417-1-AP (same clone as 12417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse bladder tissue slide using 12417-1-AP (OSBPL3 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12417-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with OSBPL3 antibody included
  • IHC staining of rat bladder using 12417-1-AP (same clone as 12417-1-PBS)

    IHC staining of rat bladder using 12417-1-AP (same clone as 12417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat bladder tissue slide using 12417-1-AP (OSBPL3 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12417-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with OSBPL3 antibody included
  • IHC staining of rat kidney using 12417-1-AP (same clone as 12417-1-PBS)

    IHC staining of rat kidney using 12417-1-AP (same clone as 12417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using 12417-1-AP (OSBPL3 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12417-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with OSBPL3 antibody included

OSBPL3 Polyclonal antibody, PBS Only

OSBPL3 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 12417-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

KIAA0704, ORP 3, ORP3, ORP-3, OSBP related protein 3

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy® OSBPL3 Ready-To-Use IHC Kit. OSBPL3 primary antibody included.

产品信息

12417-1-PBS targets OSBPL3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag3044

Product name: Recombinant human OSBPL3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-350 aa of BC017731

Sequence: MMSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISSRKRSSISKQNLFQTGSNVSFSCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQSMDVLHRTYSAPAINAIQGGSFESPKKEKRSHRRWRSRAIGKDAKGTLQVPKPFSGPVRLHSSNPNLSTLDFGEEKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 oxysterol binding protein-like 3
别名 KIAA0704, ORP 3, ORP3, ORP-3, OSBP related protein 3
计算分子量 887 aa, 101 kDa
观测分子量 95-110 kDa
GenBank蛋白编号BC017731
基因名称 OSBPL3
Gene ID (NCBI) 26031
RRIDAB_2156103
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9H4L5
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

OSBPL3 (ORP3) is an oxysterol-binding protein-related lipid transfer protein located at ER-plasma membrane contact sites. Its canonical isoform contains 887 amino acids with a theoretical molecular weight of 101.2 kDa. Western blot routinely detects a doublet around 103 kDa and 110 kDa, mainly caused by differential phosphorylation rather than splicing variants. It interacts with R-Ras and VAPA to modulate PI4P transport, actin cytoskeleton dynamics and cell adhesion. Aberrant OSBPL3 expression drives proliferation and metastasis in multiple cancers, acting as a prognostic biomarker and potential therapeutic target. (PMID: 32041906, 34584127)

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