验证数据展示
69521-1-Ig
产品信息
69521-1-PBS targets IL-17A in applications and shows reactivity with human samples.
| 经测试应用 | ELISA, Non-Neutralization Application Description |
| 经测试反应性 | human |
| 免疫原 | fusion protein 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | interleukin 17A |
| 别名 | IL 17, IL17, IL-17, IL17A, 2A7E2 |
| 基因名称 | IL-17A |
| Gene ID (NCBI) | 3605 |
| ENSEMBL Gene ID | ENSG00000112115 |
| 偶联类型 | Unconjugated |
| 纯化方式 | Protein G purification |
| UNIPROT ID | Q16552 |
| 储存缓冲液 | PBS Only, pH 7.4. |
| 储存 | Store at -80°C. |
背景介绍
IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.
This antibody is a neutralizing control antibody for IL-17A, the immunogen is the same as Neutrakine 69021-1-Ig but could not neutralize human IL-17A.