NeutraControl IL-17A Monoclonal antibody

NeutraControl IL-17A Monoclonal Antibody for Non-Neutralization, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

Non-Neutralization, ELISA

Conjugate

Unconjugated

CloneNo.

2A7E2

Cat No : 69521-1-Ig

Print datasheet

Synonyms

CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL17A, IL-17A, interleukin 17A



产品信息

69521-1-Ig targets IL-17A in Non-Neutralization applications and shows reactivity with Human samples.

Tested Applications Non-Neutralization, ELISA
Tested Reactivity Human
Immunogen human Humankine IL-17A protein HZ-1113 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name interleukin 17A
Synonyms CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL17A, IL-17A, interleukin 17A
Gene Symbol IL17A
Gene ID (NCBI) 3605
ENSEMBL Gene IDENSG00000112115
RRIDAB_2918855
Conjugate Unconjugated
Form Lyophilized Powder
Purification MethodProtein G purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

背景介绍

IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.

This antibody is a neutralizing control antibody for IL-17A, the immunogen is the same as Neutrakine 69021-1-Ig but could not neutralize human IL-17A.