Validation Data Gallery
Technical Specifications
| GeneID | 3605 |
| Species | Human |
| Expression | HEK293 |
| Activity | 0.24-1.2 ng/mL |
| Specific Activity | minimally 2.00 x 107 IU/mg |
| Purity | >95% |
| Endotoxin | <1 EU/µg |
| Accession Number | Q16552 |
| Molecular Mass | 18 and 23 kDa reduced, 29 to 34 kDa non-reduced, homodimer, glycosylated |
| Formulation | 10 mM Tris-HCl pH 7.4+ 250 mM NaCl, See Certificate of Analysis for details |
| Species Reactivity | human |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1xPBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix. |
Background
IL-17 (IL-17A) is a homodimeric glycoprotein with an apparent molecular mass of 30 to 35 kDa. The IL-17 family is comprised of at least 6 proinflammatory cytokines that share a conserved cystine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins that induce local cytokine production and recruit granulocytes to sites of inflammation (PMID: 15485625; 11574464).
Synonyms
CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, IL-17A, interleukin 17A
Publications
| Species | Title |
|---|---|
Signal Transduct Target Ther PRELP negatively regulates IL-17A-mediated proliferation and the inflammatory response in psoriasis. | |
Arthritis Rheumatol Thymidine phosphorylase regulates the expression of CXCL10 in rheumatoid arthritis fibroblast-like synoviocytes. | |
J Clin Periodontol Interleukin-17 alleviates erastin-induced alveolar bone loss by suppressing ferroptosis via interaction between NRF2 and p-STAT3 | |
Brain Behav Immun A role for fibroblast and mural cell subsets in a nerve ligation model of neuropathic pain | |
Ann Allergy Asthma Immunol Epithelial histone deacetylase 7 (HDAC7) constitutes a negative feedback loop restraining interleukin (IL)-13-driven eosinophilic inflammation in chronic rhinosinusitis |
