验证数据展示
产品信息
85939-4-PBS targets NUMB in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | WB, IHC, IP, Indirect ELISA Application Description |
经测试反应性 | human, mouse, rat |
免疫原 | NUMB fusion protein Ag31553 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | numb homolog (Drosophila) |
别名 | C14orf41, h Numb, h-Numb |
计算分子量 | 71KD |
观测分子量 | 66-71 kDa |
GenBank蛋白编号 | NM_001005743 |
基因名称 | NUMB |
Gene ID (NCBI) | 8650 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P49757 |
储存缓冲液 | PBS only, pH 7.3. |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
NUMB, also named as S171, plays a role in the determination of cell fates during development. It is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The degradation of NUMB is induced in a proteasome-dependent manner by MDM2. Four transcript variants encoding different isoforms have been found for this gene.