验证数据展示
产品信息
85004-1-PBS targets NCOA5 in IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
经测试应用 | IF/ICC, FC (Intra), Indirect ELISA Application Description |
经测试反应性 | human |
免疫原 | NCOA5 fusion protein Ag14418 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | nuclear receptor coactivator 5 |
别名 | Nuclear receptor coactivator 5, NCoA-5, KIAA1637, Coactivator independent of AF-2, CIA |
计算分子量 | 579 aa, 66 kDa |
GenBank蛋白编号 | BC056872 |
基因名称 | NCOA5 |
Gene ID (NCBI) | 57727 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purfication |
UNIPROT ID | Q9HCD5 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Nuclear receptor coactivator 5 (NCOA5), also known as a coactivator independent of AF-2 (CIA), possesses both repressor and activator functions (PMID: 11113208). It can interact with Estrogen Receptor (ER) alpha and ER beta in a ligand-dependent manner. NCOA5 has been shown to regulate the ER alpha-mediated transcription and the c-Myc gene expression (PMID: 11113208; 15073177). Recently identified as a conserved component of pluripotent stem cells, mammalian NCOA5 may contribute to maintaining the pluripotent stem cell population (PMID: 24268775).