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验证数据展示

  • WB analysis using 13488-1-AP (same clone as 13488-1-PBS)

    WB analysis using 13488-1-AP (same clone as 13488-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 13488-1-AP (MTMR4 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13488-1-PBS in a different storage buffer formulation.

  • WB analysis of MCF-7 using 13488-1-AP (same clone as 13488-1-PBS)

    WB analysis of MCF-7 using 13488-1-AP (same clone as 13488-1-PBS)

    WB result of MTMR4 antibody (13488-1-AP; 1:600; incubated at room temperature for 1.5 hours) with sh-Control and sh-MTMR4 transfected MCF-7 cells. This data was developed using the same antibody clone with 13488-1-PBS in a different storage buffer formulation.

  • WB analysis using 13488-1-AP (same clone as 13488-1-PBS)

    WB analysis using 13488-1-AP (same clone as 13488-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 13488-1-AP (MTMR4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13488-1-PBS in a different storage buffer formulation.

  • IHC staining of Hepatocellular carcinoma using 13488-1-AP (same clone as 13488-1-PBS)

    IHC staining of Hepatocellular carcinoma using 13488-1-AP (same clone as 13488-1-PBS)

    Immunohistochemical analysis of paraffin-embedded hepatocellular carcinoma tissue slide using 13488-1-AP (MTMR4 antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13488-1-PBS in a different storage buffer formulation.

  • IHC staining of rat testis using 13488-1-AP (same clone as 13488-1-PBS)

    IHC staining of rat testis using 13488-1-AP (same clone as 13488-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat testis tissue slide using 13488-1-AP (MTMR4 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13488-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 13488-1-AP (same clone as 13488-1-PBS)

    IF Staining of HepG2 using 13488-1-AP (same clone as 13488-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using MTMR4 antibody (13488-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 13488-1-PBS in a different storage buffer formulation.

  • IHC staining of rat testis using 13488-1-AP (same clone as 13488-1-PBS)

    IHC staining of rat testis using 13488-1-AP (same clone as 13488-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat testis tissue slide using 13488-1-AP (MTMR4 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13488-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

MTMR4 Polyclonal antibody, PBS Only

MTMR4 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 13488-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

EC:3.1.3.48, FYVE domain-containing dual specificity protein phosphatase 2, FYVE DSP2, FYVE-DSP2, KIAA0647

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

13488-1-PBS targets MTMR4 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag4310

Product name: Recombinant human MTMR4 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 845-1195 aa of BC035609

Sequence: SHQEQLSSVPDLTHGEEDIGKRGNNRNGQLLENPRFGKMPLELVRKPISQSQISEFSFLGSNWDSFQGMVTSFPSGEATPRRLLSYGCCSKRPNSKQMRATGPCFGGQWAQREGVKSPVCSSHSNGHCTGPGGKNQMWLSSHPKQVSSTKPVPLNCPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYKQEVEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDCLSEASWEPVDKKETEVTRWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIPDQQLYDPVLVCNSCYEHIQVSRARELMSQQLKKPIATASS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 myotubularin related protein 4
别名 EC:3.1.3.48, FYVE domain-containing dual specificity protein phosphatase 2, FYVE DSP2, FYVE-DSP2, KIAA0647
计算分子量 1195 aa, 133 kDa
观测分子量 133-150 kDa
GenBank蛋白编号BC035609
基因名称 MTMR4
Gene ID (NCBI) 9110
RRIDAB_2251008
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9NYA4
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Myotubularin-related protein-4 (MTMR4), also named FYVE-DSP2, is a member of the myotubularin family of phosphoinositide phosphatases that selectively degrade the 3-position phosphate from the inositol ring of PtdIns(3)P and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PMID: 31543504). MTMR4 knockdown markedly suppressed the motility, fusion, and fission of PI(3)P- enriched structures, resulting in decreases in late endosomes, autophagosomes, and lysosomes, and enlargement of PI(3)P- enriched early and late endosomes(PMID: 29962048).

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