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验证数据展示

  • WB analysis of BT-474 using 87911-1-RR (same clone as 87911-1-PBS)

    WB analysis of BT-474 using 87911-1-RR (same clone as 87911-1-PBS)

    BT-474 cells were subjected to SDS PAGE followed by western blot with 87911-1-RR (MIEN1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87911-1-PBS in a different storage buffer formulation.

  • WB analysis using 87911-1-RR (same clone as 87911-1-PBS)

    WB analysis using 87911-1-RR (same clone as 87911-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87911-1-RR (MIEN1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87911-1-PBS in a different storage buffer formulation.

  • Affinity of 87911-1-RR

    Affinity of 87911-1-RR

    Biolayer interferometry (BLI) kinetic assays of 87911-1-RR against Human MIEN1 were performed. The affinity constant is 2.40 nM.

MIEN1 Recombinant monoclonal antibody, PBS Only

MIEN1 Uni-rAb® Recombinant Antibody for WB, Indirect ELISA
Cat No. 87911-1-PBS

产品说明书

CloneNo. 252392C9

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Indirect ELISA

别名

C17orf37, C35, HBV XAg-transactivated protein 4, HBV X-transactivated gene 4 protein, Migration and invasion enhancer 1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

87911-1-PBS targets MIEN1 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Eg5748

Product name: Recombinant Human MIEN1 protein (rFc Tag)

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 2-115 aa of NM_032339.5

Sequence: SGEPGQTSVAPPPEEVEPGSGVRIVVEYCEPCGFEATYLELASAVKEQYPGIEIESRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIRRASNGETLEKITNSRPPCVIL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 chromosome 17 open reading frame 37
别名 C17orf37, C35, HBV XAg-transactivated protein 4, HBV X-transactivated gene 4 protein, Migration and invasion enhancer 1
计算分子量12 kDa
观测分子量12 kDa
GenBank蛋白编号NM_032339.5
基因名称 C17orf37
Gene ID (NCBI) 84299
RRIDAB_3745822
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ9BRT3
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MIEN1 (Migration and Invasion Enhancer 1), also known as C17orf37 or RDEP, is a protein-coding gene located in the q12 region of chromosome 17. Through prenylation modification, this protein anchors to the inner side of the cell membrane, promotes actin cytoskeleton rearrangement and membrane ruffling, thereby enhancing the migration and invasion capabilities of tumor cells. MIEN1 is highly expressed in various malignant tumors, including breast cancer, prostate cancer, and lung cancer, and its expression level is closely correlated with tumor metastasis, clinical stage, and poor patient prognosis. Moreover, MIEN1 promotes epithelial-mesenchymal transition (EMT) by regulating signaling pathways such as PI3K/AKT and NF-κB, making it a potential anti-metastatic therapeutic target and prognostic marker.

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