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Linsidomine hydrochloride

Linsidomine hydrochloride (SIN-1 chloride) 是莫西多明的代谢产物，具有舒张血管、抑制血小板聚集和抗心绞痛的活性。在心肌缺血-再灌注模型中，Linsidomine hydrochloride 减少心肌坏死和再灌注诱导的内皮功能障碍，与海绵体的作用机制涉及一氧化氮的释放有关。

CAS号

16142-27-1

分子式

C6H11ClN4O2

主要靶点

ROS|Autophagy|Apoptosis|Annexin A|NF-κB|Drug Metabolite

仅限科研使用

Cat No : CM11744

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Synonyms

DrugMetabolite|Drug Metabolite|Linsidomine Hydrochloride|林西多明盐酸盐|SIN 1 Chloride|SIN1 Chloride|SIN-1 Chloride|SIN-1 chloride

验证数据展示

  • CAS No.: 16142-27-1

    Linsidomine hydrochloride
    CAS#: 16142-27-1

产品信息

Linsidomine hydrochloride (SIN-1 chloride) is considered as a metabolite of moxidomine, with vasodilation, inhibition of platelet aggregation, and antiangina activity. In myocardial ischemia-reperfusion models, Linsidomine hydrochloride to reduce myocardial necrosis and reperfusion induced endothelial dysfunction is associated with the cavernosal mechanism of action involved in nitric oxide release.

CAS号 16142-27-1
分子式 C6H11ClN4O2
主要靶点 ROS|Autophagy|Apoptosis|Annexin A|NF-κB|Drug Metabolite
主要通路 代谢
分子量 206.63
纯度 99.67%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
别名 DrugMetabolite|Drug Metabolite|Linsidomine Hydrochloride|林西多明盐酸盐|SIN 1 Chloride|SIN1 Chloride|SIN-1 Chloride|SIN-1 chloride

体内活性

SIN-1 (chloride) 是莫索明的活性代谢产物。它显示出强大的血管舒张效应和抑制血小板聚集的功能。[1]在心肌缺血-再灌注模型中，SIN-1（氯化物）能降低心肌坏死和减轻再灌注引起的内皮功能障碍。[2]

体外活性

SIN-1 在心肌缺血-再灌注模型中减少心肌坏死和再灌注引起的内皮功能障碍[1][2]。

溶解度

10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (9.68 mM);H2O:45 mg/mL (217.78 mM);DMSO:22.5 mg/mL (108.89 mM)

参考文献

1.Nishikawa M, et al. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites. J Pharmacol Exp Ther. 1982;220(1):183-190.
2.Siegfried MR, et al. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther. 1992;260(2):668-675.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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