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验证数据展示

  • WB analysis using 84203-5-RR (same clone as 84203-5-PBS)

    WB analysis using 84203-5-RR (same clone as 84203-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84203-5-RR (KCNJ18 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84203-5-PBS in a different storage buffer formulation.

  • IHC staining of mouse skin using 84203-5-RR (same clone as 84203-5-PBS)

    IHC staining of mouse skin using 84203-5-RR (same clone as 84203-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 84203-5-RR (KCNJ18 antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84203-5-PBS in a different storage buffer formulation.

  • IF Staining of mouse skin using 84203-5-RR (same clone as 84203-5-PBS)

    IF Staining of mouse skin using 84203-5-RR (same clone as 84203-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse skin tissue using KCNJ18 antibody (84203-5-RR, Clone: 241381A2 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84203-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84203-5-RR

    Affinity and Kinetic Characterization of 84203-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84203-5-RR against Human KCNJ18 were performed. The affinity constant is below 3.06 nM.

KCNJ18 Recombinant monoclonal antibody, PBS Only

KCNJ18 Uni-rAb® Recombinant Antibody for WB, IHC, IF-P, Indirect ELISA
Cat No. 84203-5-PBS

产品说明书

CloneNo. 241381A2

宿主/亚型

Rabbit / IgG

种属反应性

mouse, rat

应用

WB, IHC, IF-P, Indirect ELISA

别名

TTPP2, KIR2.6, Inward rectifier potassium channel 18, 241381A2

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84203-5-PBS targets KCNJ18 in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with mouse, rat samples.

经测试应用 WB, IHC, IF-P, Indirect ELISA Application Description
经测试反应性 mouse, rat
免疫原

CatNo: Ag34177

Product name: Recombinant human KCNJ18 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 353-433 aa of NM_001194958

Sequence: STPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGGVLEQRPYRRGSEI

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 similar to hkir2.2x
别名 TTPP2, KIR2.6, Inward rectifier potassium channel 18, 241381A2
计算分子量 49 kDa
观测分子量45 kDa
GenBank蛋白编号NM_001194958
基因名称 KCNJ18
Gene ID (NCBI) 100134444
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDB7U540
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Mutations in KCNJ18 gene encoding an inwardly rectifying potassium channel (Kir2.6) cause thyrotoxic periodic paralysis (TPP) and sporadic, that is, non-familial cases of HypoPP. Mutant Kir2.6 proteins form a heterotetrameric Kir channel complex with Kir2.1 and thereby reduce cell surface expression of the complex. (PMID: 25882930)

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