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验证数据展示

  • WB analysis of mouse brain using 12032-1-AP (same clone as 12032-1-PBS)

    WB analysis of mouse brain using 12032-1-AP (same clone as 12032-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 12032-1-AP (KCNIP3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12032-1-PBS in a different storage buffer formulation.

  • IHC staining of human gliomas using 12032-1-AP (same clone as 12032-1-PBS)

    IHC staining of human gliomas using 12032-1-AP (same clone as 12032-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 12032-1-AP (KCNIP3 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 12032-1-PBS in a different storage buffer formulation.

  • IHC staining of human gliomas using 12032-1-AP (same clone as 12032-1-PBS)

    IHC staining of human gliomas using 12032-1-AP (same clone as 12032-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 12032-1-AP (KCNIP3 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 12032-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 12032-1-AP (same clone as 12032-1-PBS)

    IP experiment of mouse brain using 12032-1-AP (same clone as 12032-1-PBS)

    IP result of anti-KCNIP3 (IP:12032-1-AP, 4ug; Detection:12032-1-AP 1:1000) with mouse brain tissue lysate 4400 ug. This data was developed using the same antibody clone with 12032-1-PBS in a different storage buffer formulation.

  • IF Staining of SH-SY5Y using 12032-1-AP (same clone as 12032-1-PBS)

    IF Staining of SH-SY5Y using 12032-1-AP (same clone as 12032-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed SH-SY5Y cells using KCNIP3 antibody (12032-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 12032-1-PBS in a different storage buffer formulation.

KCNIP3 Polyclonal antibody, PBS Only

KCNIP3 Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 12032-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IF/ICC, IP, Indirect ELISA

别名

A-type potassium channel modulatory protein 3, Calsenilin, DRE-antagonist modulator, Kv channel-interacting protein 3

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

12032-1-PBS targets KCNIP3 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag2665

Product name: Recombinant human KCNIP3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-256 aa of BC012850

Sequence: MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 Kv channel interacting protein 3, calsenilin
别名 A-type potassium channel modulatory protein 3, Calsenilin, DRE-antagonist modulator, Kv channel-interacting protein 3
计算分子量 256 aa, 29 kDa
观测分子量 29 kDa, 27 kDa
GenBank蛋白编号BC012850
基因名称 KCNIP3
Gene ID (NCBI) 30818
RRIDAB_2234348
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9Y2W7
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

KCNIP3 also known as Calsenilin, CSEN, DREAM, or KCHIP3, is a protein-coding gene located on human chromosome 2q11.1 . It encodes a small calcium-binding protein belonging to the recoverin branch of the EF-hand superfamily. KCNIP3 is an integral subunit of native Kv4 channel complexes, regulating A-type potassium currents in response to intracellular calcium changes, thereby modulating neuronal excitability. KCNIP3 interacts with presenilin 1 (PSEN1) and presenilin 2 (PSEN2), influencing γ-secretase activity and β-amyloid formation, potentially linking it to Alzheimer's disease pathology.

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