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验证数据展示

  • WB analysis using 21302-1-AP (same clone as 21302-1-PBS)

    WB analysis using 21302-1-AP (same clone as 21302-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21302-1-AP (JAML antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21302-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 21302-1-AP (same clone as 21302-1-PBS)

    IHC staining of human spleen using 21302-1-AP (same clone as 21302-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen using 21302-1-AP (JAML antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 21302-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 21302-1-AP (same clone as 21302-1-PBS)

    IHC staining of human spleen using 21302-1-AP (same clone as 21302-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen using 21302-1-AP (JAML antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 21302-1-PBS in a different storage buffer formulation.

JAML Polyclonal antibody, PBS Only

JAML Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 21302-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

Gm638, Dendritic cell-specific protein CREA7-1, CREA7 4, CREA7 1, AMICA1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

21302-1-PBS targets JAML in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag15900

Product name: Recombinant human AMICA1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 40-275 aa of BC100797

Sequence: VPIGRFQNRVHLMGDILCNDGSLLLQDVQEADQGTYICEIRLKGESQVFKKAVVLHVLPEEPKELMVHVGGLIQMGCVFQSTEVKHVTKVEWIFSGRRAKEEIVFRYYHKLRMSVEYSQSWGHFQNRVNLVGDIFRNDGSIMLQGVRESDGGNYTCSIHLGNLVFKKTIVLHVSPEEPRTLVTPAALRPLVLGGNQLVIIVGIVCATILLLPVLILIVKKTCGNKSSVNSTVLVKN

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 adhesion molecule, interacts with CXADR antigen 1
别名 Gm638, Dendritic cell-specific protein CREA7-1, CREA7 4, CREA7 1, AMICA1
计算分子量 394 aa, 44 kDa
观测分子量 44 kDa, 50-70 kDa
GenBank蛋白编号BC100797
基因名称 JAML
Gene ID (NCBI) 120425
RRIDAB_10733103
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ86YT9
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Junctional adhesion molecules (JAM-A, JAM-B, and JAM-C) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites (PMID: 19064666). JAML (junctional adhesion molecule-like), also known as AMICA1, is related to JAM proteins. It contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail. JAML is expressed on leukocytes and promotes their adhesion to endothelial cells (PMID: 12869515). JAML can regulate neutrophil transepithelial migration via binding interactions with epithelial coxsackie and adenovirus receptor (CAR) (PMID: 15800062). The full-length human JAML protein has a calculated molecular weight of 44 kDa. This antibody raised against 40-275 aa of human JAML protein detects bands with molecular wight of 44 kDa, and 50-70 kDa which probably represent different glycoforms of the protein (PMID: 12869515; 24621992; 15800062).

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