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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • FC experiment of human PBMCs using 98292-1-RR (same clone as 98292-1-PBS)

    FC experiment of human PBMCs using 98292-1-RR (same clone as 98292-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human IL-10RB Rabbit RecAb (98292-1-RR, Clone: 242302D2) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Human HLA-DR (L243) Mouse IgG2a Recombinant Antibody (CL647-65560, Clone: L243). Cells were not fixed. This data was developed using the same antibody clone with 98292-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98292-1-RR (same clone as 98292-1-PBS)

    FC experiment of human PBMCs using 98292-1-RR (same clone as 98292-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human IL-10RB Rabbit RecAb (98292-1-RR, Clone:242302D2) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98292-1-PBS in a different storage buffer formulation.

Anti-Human IL-10RB Rabbit Recombinant Antibody, PBS Only

IL-10RB Uni-rAbTM Recombinant Antibody for FC
Cat No. 98292-1-PBS

产品说明书

CloneNo. 242302D2

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

IL10RB, Cytokine receptor class-II member 4, CRFB4, CRF2-4, CRF2 4

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98292-1-PBS targets IL-10RB in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 10 receptor, beta
别名 IL10RB, Cytokine receptor class-II member 4, CRFB4, CRF2-4, CRF2 4
计算分子量 37 kDa
GenBank蛋白编号BC001903
基因名称 IL10RB
Gene ID (NCBI) 3588
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ08334
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in maintaining immune system balance. IL-10 signals through a receptor complex consisting of two molecules of the IL-10R alpha-chain (IL-10RA) and two molecules of the accessory IL-10R beta-chain (IL-10RB) (PMID: 22236434). IL-10RA and IL-10RB are members of the type II cytokine receptor family. IL-10RB, also known as IL-10R2 or CDw210b, is the signaling subunit of the IL-10R complex and is constitutively expressed in a variety of cell types (PMID: 24507158). Binding of IL-10 to the IL-10R complex leads to JAK1- and TYK2-mediated phosphorylation of STAT3 (PMID: 11244051; 10433356). IL-10RB is also shared by several other cytokines, including IL22, IL-26, IFN-γ, IL-28A/B and IL29 (PMID: 22236434).