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验证数据展示

  • WB analysis using 67106-1-Ig (same clone as 67106-1-PBS)

    WB analysis using 67106-1-Ig (same clone as 67106-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67106-1-Ig (IDE antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67106-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 67106-1-Ig (same clone as 67106-1-PBS)

    WB analysis of HeLa using 67106-1-Ig (same clone as 67106-1-PBS)

    WB result of IDE antibody (67106-1-Ig; 1:10000; incubated at room temperature for 1.5 hours) with sh-Control and sh-IDE transfected HeLa cells. This data was developed using the same antibody clone with 67106-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse liver using 67106-1-Ig (same clone as 67106-1-PBS)

    IHC staining of mouse liver using 67106-1-Ig (same clone as 67106-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 67106-1-Ig (IDE antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67106-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse liver using 67106-1-Ig (same clone as 67106-1-PBS)

    IHC staining of mouse liver using 67106-1-Ig (same clone as 67106-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 67106-1-Ig (IDE antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67106-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

IDE Monoclonal antibody, PBS Only

IDE Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 67106-1-PBS

产品说明书

CloneNo. 3E10G1

宿主/亚型

Mouse / IgG2b

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

Insulin-degrading enzyme, Insulinase, Insulin protease, EC:3.4.24.56, Abeta-degrading protease

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

67106-1-PBS targets IDE in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag17161

Product name: Recombinant human IDE protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 676-1019 aa of BC096336

Sequence: EQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL

种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 Abeta degrading protease
别名 Insulin-degrading enzyme, Insulinase, Insulin protease, EC:3.4.24.56, Abeta-degrading protease
计算分子量 1019 aa, 118 kDa
观测分子量 100-120 kDa
GenBank蛋白编号BC096336
基因名称 IDE
Gene ID (NCBI) 3416
RRIDAB_2882410
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP14735
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IDE(INS-degrading enzyme) belongs to the peptidase M16 family. It is also known as insulysin and is a 110-kD neutral metallopeptidase that can degrade a number of peptides, including INS and beta-amyloid(PMID:9830016). The reduction of IDE expression may be a risk factor for AD, and that IDE may interact with APOE status to affect beta-amyloid metabolism(PMID:12507914). It can exsit as a homodimer and form higher oligomers(PMID:17613531).

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