验证数据展示
产品信息
98758-3-PBS targets IgA1 in FC applications and shows reactivity with human samples.
| 经测试应用 | FC Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Eg9190 Product name: Recombinant human IgA1-IgK protein Source: mammalian cells-derived, pHZ-KIsec-C-6*HIS Tag: C-6*HIS Sequence: \ 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | immunoglobulin heavy constant alpha 1 |
| 别名 | Human IgA, Human IgA Heavy Chain, IGHA1, IgA, Igh2 |
| 基因名称 | Human IgA Heavy Chain |
| Gene ID (NCBI) | 3493 |
| RRID | AB_3746325 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Immunoglobulins (Ig), also known as antibodies, are glycoproteins produced by B cells and plasma cells. There are 5 main classes of mammalian immunoglobulin heavy chains. Each class defines the IgM, IgG, IgA, IgD, and IgE isotypes (PMID: 20176268). IgA is the most prevalent antibody class at mucosal sites with an important role in mucosal defense. There are 2 subclasses of IgA, IgA1 and IgA2, which differ over a stretch of 18 amino acids in their hinge region, with the hinge of IgA1 being 13 amino acids longer than that of IgA2 (PMID: 21691145). This antibody specifically recognizes human IgA1 and does not cross-react with IgA2.
