验证数据展示
产品信息
83221-2-PBS targets KIM-1/HAVCR1 in WB, Cytometric bead array, Indirect ELISA applications and shows reactivity with mouse, rat samples.
| 经测试应用 | WB, Cytometric bead array, Indirect ELISA Application Description |
| 经测试反应性 | mouse, rat |
| 免疫原 | KIM-1/HAVCR1 fusion protein Eg0597 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | hepatitis A virus cellular receptor 1 |
| 别名 | HAVCR1, KIM-1, TIM-1, 230528C5, CD365 |
| 计算分子量 | 34 kDa |
| 观测分子量 | 72 kDa |
| GenBank蛋白编号 | NM_173149.2 |
| 基因名称 | Havcr1 |
| Gene ID (NCBI) | 286934 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | O54947 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Kidney injury molecule 1 (KIM-1), also known as Hepatitis A virus cellular receptor 1 (HAVCR1), CD365, or T-cell immunoglobulin and mucin domain 1 (TIM-1), is a class I integral membrane glycoprotein, with an ectodomain containing Ig-like domain and a mucin domain. KIM-1 acts as a membrane receptor for hepatitis A virus (HAV) (PMID: 9658108; 8861957). KIM-1 provides a costimulatory signal for T cell activation and inhibits the development of peripheral tolerance (PMID: 16284246; 15793575). KIM-1 may be involved in the regulation of asthma and allergic diseases (PMID: 14534576). It has been reported that KIM-1 is shed into urine after acute kidney damage and is a marker of renal tubular injury (PMID: 14600030).