验证数据展示
产品信息
68233-1-PBS targets GPSM1 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.
经测试应用 | WB, IF/ICC, Indirect ELISA Application Description |
经测试反应性 | Human, mouse, rat |
免疫原 | GPSM1 fusion protein Ag18773 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | G-protein signaling modulator 1 (AGS3-like, C. elegans) |
别名 | AGS3, DKFZp727I051, GPSM1 |
计算分子量 | 652 aa, 72 kDa |
观测分子量 | 75 kDa |
GenBank蛋白编号 | BC017353 |
基因名称 | GPSM1 |
Gene ID (NCBI) | 26086 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein G purification |
UNIPROT ID | Q86YR5 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
GPSM1, also named as AGS3, is a receptor-independent G protein activator that has been implicated in multiple biological events such as brain development, neuroplasticity and addiction, cardiac function, Golgi structure/function, macroautophagy and metabolism. It contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. It has been shown that AGS3 could regulate the orientation of the mitotic spindle, cAMP production, membrane protein transport, and asymmetric cell division by binding preferentially to inactive Gai/o subunits complexed with guanine dinucleotide phosphate (GDP) at multiple G-protein regulatory or GoLoco motif repeats. It also plays an important anti-apoptotic role through enhancing the phosphorylation of cyclic AMP response element-binding protein (p-CREB).