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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • FC experiment of mouse splenocytes using 98466-3-RR (same clone as 98466-3-PBS)

    FC experiment of mouse splenocytes using 98466-3-RR (same clone as 98466-3-PBS)

    1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse GITR/TNFRSF18 Rabbit RecAb (98466-3-RR, Clone: 250666B12) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Mouse CD25/IL-2RA (PC61.5) (APC-65137, Clone: PC61.5). CD4+ cells were pre-gated for analysis. Cells were not fixed. This data was developed using the same antibody clone with 98466-3-PBS in a different storage buffer formulation.

  • FC experiment of mouse splenocytes using 98466-3-RR (same clone as 98466-3-PBS)

    FC experiment of mouse splenocytes using 98466-3-RR (same clone as 98466-3-PBS)

    1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse GITR/TNFRSF18 Rabbit RecAb (98466-3-RR, Clone:250666B12) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). CD4+ cells were pre-gated for analysis. Cells were not fixed. This data was developed using the same antibody clone with 98466-3-PBS in a different storage buffer formulation.

Anti-Mouse GITR/TNFRSF18 Rabbit Recombinant Antibody, PBS Only

GITR/TNFRSF18 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98466-3-PBS

产品说明书

CloneNo. 250666B12

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC

别名

CD357, GITR, Tnfrsf18, AITR, Glucocorticoid-induced TNFR-related protein

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98466-3-PBS targets GITR/TNFRSF18 in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
经测试反应性 mouse
免疫原 GITR/TNFRSF18 fusion protein Eg3695 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tumor necrosis factor receptor superfamily, member 18
别名 CD357, GITR, Tnfrsf18, AITR, Glucocorticoid-induced TNFR-related protein
计算分子量25kDa
GenBank蛋白编号NM_009400.2
基因名称 CD357
Gene ID (NCBI) 21936
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDO35714-1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Glucocorticoid-induced TNFR-related protein (GITR), also known as CD357 or TNFRSF18, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is expressed constitutively at high levels in T regulatory cells (Treg cells) and plays a key role in dominant immunological self-tolerance maintained by CD25+CD4+ regulatory T cells (PMID: 11812990). It is expressed at low levels on resting responder T cells. The expression of GITR on T cells can be upregulated upon activation (PMID: 15770698). GITR is activated by GITR ligand (GITRL) which is mainly expressed on APC. GITR-GITRL interactions could co-stimulate both responder T-cell functions and the suppressive functions of Treg cells (PMID: 16868552).