验证数据展示
产品信息
84807-5-PBS targets Endoglin/CD105 in WB, Indirect ELISA applications and shows reactivity with mouse samples.
经测试应用 | WB, Indirect ELISA Application Description |
经测试反应性 | mouse |
免疫原 | Recombinant protein 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | endoglin |
别名 | CD105, 242305A11, S endoglin, Eng, endoglin |
计算分子量 | 70kDa |
观测分子量 | 90 kDa |
GenBank蛋白编号 | NM_007932.2 |
基因名称 | CD105 |
Gene ID (NCBI) | 13805 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purfication |
UNIPROT ID | Q63961 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 90-95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)