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验证数据展示

  • IF Staining of hTERT-RPE1 using CL594-29758

    IF Staining of hTERT-RPE1 using CL594-29758

    Immunofluorescent analysis of (4% PFA) fixed hTERT-RPE1 cells using CoraLite®594 DYNC2H1 antibody (CL594-29758) at dilution of 1:200, CoraLite® Plus 488 ARL13B antibody (CL488-17711, green).

CoraLite®594-conjugated DYNC2H1 Polyclonal antibody

DYNC2H1 Polyclonal Antibody for IF/ICC
Cat No. CL594-29758

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IF/ICC

别名

DHC1b, DHC2, DNCH2, DYH1B, hdhc11

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite®594
规格价格库存

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经过测试的应用

Positive IF/ICC detected inhTERT-RPE1 cells
For other applications, we recommend the unconjugated version of this antibody, 29758-1-AP

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL594-29758 targets DYNC2H1 in IF/ICC applications and shows reactivity with human, mouse samples.

经测试应用 IF/ICC Application Description
经测试反应性 human, mouse
免疫原 DYNC2H1 fusion protein Ag30707 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 dynein, cytoplasmic 2, heavy chain 1
别名 DHC1b, DHC2, DNCH2, DYH1B, hdhc11
计算分子量 493 kDa
观测分子量493 kDa
GenBank蛋白编号NM_001377
基因名称 DYNC2H1
Gene ID (NCBI) 79659
偶联类型 CoraLite®594 Fluorescent Dye
最大激发/发射波长588 nm / 604 nm
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8NCM8
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

DYNC2H1 (Cytoplasmic dynein 2 heavy chain 1) is involved in ciliary intraflagellar transport (IFT). DYNC2H1 drives retrograde transport of the IFT-A protein complex that regulates tip-to-base transport in cilia, involved in the generation and maintenance of cilia. DYNC2H1 variants or retina-predominant variants cause nonsyndromic retinal degeneration (PMID:32753734). DYNC2H1 mutations also cause asphyxiating thoracic dystrophy and short rib-polydactyly syndrome (PMID: 19442771). DYNC2H1 was localized to the basal bodies by immunofluorescence staining (PMID: 21552265, PMID: 26077881, PMID: 30320547).

实验方案

Product Specific Protocols
IF protocol for CL594 DYNC2H1 antibody CL594-29758Download protocol
Standard Protocols
Click here to view our Standard Protocols