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验证数据展示

  • IHC staining of human pancreas cancer using 66167-1-Ig (same clone as 66167-1-PBS)

    IHC staining of human pancreas cancer using 66167-1-Ig (same clone as 66167-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 66167-1-Ig (Claudin 18 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Claudin 18 antibody included
  • IP experiment of mouse stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    IP experiment of mouse stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    IP result of anti-Claudin 18 (IP:66167-1-Ig, 3ug; Detection:66167-1-Ig 1:300) with mouse stomach tissue lysate 4000ug. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Claudin 18 antibody included
  • IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Claudin 18 antibody included

Claudin 18 Monoclonal antibody, PBS Only

Claudin 18 Monoclonal Antibody for IHC, IP, Indirect ELISA
Cat No. 66167-1-PBS

产品说明书

CloneNo. 5G7F2

宿主/亚型

Mouse / IgG2a

种属反应性

human, mouse

应用

IHC, IP, Indirect ELISA

别名

UNQ778/PRO1572, CLDN18, Claudin-18, Claudin18, 5G7F2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy Claudin 18 Ready-To-Use IHC Kit. Claudin 18 primary antibody included.

产品信息

66167-1-PBS targets Claudin 18 in IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag15517

Product name: Recombinant human CLDN18 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 185-261 aa of BC146668

Sequence: TLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV

种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 claudin 18
别名 UNQ778/PRO1572, CLDN18, Claudin-18, Claudin18, 5G7F2
计算分子量 261 aa, 28 kDa
观测分子量 29 kDa
GenBank蛋白编号BC146668
基因名称 CLDN18
Gene ID (NCBI) 51208
RRIDAB_2881563
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP56856
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Claudin 18 (CLDN18) belongs to the large claudin family of proteins, which are tetraspan transmembrane proteins of tight junctions (PMID: 11585919; 18036336). Claudins exhibit specific patterns of expression in different tissues (PMID: 15447685). CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific (PMID: 11585919; 21832145). Altered CLDN18 expression has been reported in various human malignancies, including gastric cancer, lung adenocarcinoma, and pancreatic neoplasm (PMID: 17459057; 22076167; 21832145). This antibody can recognize both CLDN18.1 and CLDN18.2.