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验证数据展示

  • FC experiment of human monocyte-derived mature dendritic cells using 65581-1-MR (same clone as 65581-1-PBS)

    FC experiment of human monocyte-derived mature dendritic cells using 65581-1-MR (same clone as 65581-1-PBS)

    1x10^6 human monocyte-derived mature dendritic cells were surface stained with 0.25 ug Anti-Human CD83 Mouse IgG2a Recombinant Antibody (65581-1-MR, Clone: HB15e) (red) or 0.25 ug Mouse IgG2a Isotype Control (65208-1-Ig, Clone: C1.18.4) (blue) and CoraLite®488-Conjugated AffiniPure Donkey Anti-Mouse IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 65581-1-PBS in a different storage buffer formulation.

  • IF Staining of Raji using 65581-1-MR (same clone as 65581-1-PBS)

    IF Staining of Raji using 65581-1-MR (same clone as 65581-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed Raji cells using CD83 antibody (65581-1-MR, Clone: HB15e ) at dilution of 1:100 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). This data was developed using the same antibody clone with 65581-1-PBS in a different storage buffer formulation.

Anti-Human CD83 (HB15e) Mouse IgG2a Recombinant Antibody, PBS Only

CD83 Uni-rAb® Recombinant Antibody for IF/ICC, FC
Cat No. 65581-1-PBS

产品说明书

CloneNo. HB15e

宿主/亚型

Mouse / IgG2a

种属反应性

human, non-human primates

应用

IF/ICC, FC

别名

B cell activation protein, B-cell activation protein, BL11, CD83 antigen, CD83 molecule

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

65581-1-PBS targets CD83 in IF/ICC, FC applications and shows reactivity with human, non-human primates samples.

经测试应用 IF/ICC, FC Application Description
经测试反应性 human, non-human primates
免疫原

Human CD83-transfected Cos cells

种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Recombinant
产品类型 Antibody
全称 CD83 molecule
别名 B cell activation protein, B-cell activation protein, BL11, CD83 antigen, CD83 molecule
计算分子量 205 aa, 23 kDa
GenBank蛋白编号BC030830
基因名称 CD83
Gene ID (NCBI) 9308
ENSEMBL Gene IDENSG00000112149
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ01151
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD83 is a member of the immunoglobulin (Ig) superfamily, consisting of an extracellular V-type Ig-like domain, a transmembrane domain, and a cytoplasmic tail. CD83 is one of the most prominent markers for fully matured dendritic cells (DCs) (PMID: 17334966). It is also found on the surface of other activated hematopoietic cells, including lymphocytes, monocytes, macrophages, and neutrophils (PMID: 31231400; 17334966). CD83 regulates the maturation, activation, and homeostasis of numerous immune cells (PMID: 31231400; 32362900). CD83 can also expressed as a soluble form. Soluble CD83 can bind to DCs and inhibit their maturation (PMID: 17334966; 12403928).

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