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验证数据展示

  • FC experiment of Mouse splenic leucocytes using 98212-1-RR (same clone as 98212-1-PBS)

    FC experiment of Mouse splenic leucocytes using 98212-1-RR (same clone as 98212-1-PBS)

    1x10^6 untreated or LPS treated mouse splenic leukocytes were surface stained with 0.25 ug Anti-Mouse CD70 Rabbit Recombinant Antibody (98212-1-RR, Clone: 241553F2) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98212-1-PBS in a different storage buffer formulation.

  • FC experiment of Mouse splenic leucocytes using 98212-1-RR (same clone as 98212-1-PBS)

    FC experiment of Mouse splenic leucocytes using 98212-1-RR (same clone as 98212-1-PBS)

    1x10^6 LPS treated mouse splenic leukocytes were surface stained with 0.25 ug Anti-Mouse CD70 Rabbit Recombinant Antibody (98212-1-RR, Clone: 241553F2) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 LPS treated Mouse splenic leucocytes were surface stained with 0.25 ug Anti-Mouse CD70 Rabbit Recombinant Antibody (98212-1-RR, Clone: 241553F2) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98212-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98212-1-RR

    Affinity and Kinetic Characterization of 98212-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98212-1-RR against Mouse CD70 were performed. The affinity constant is 37.8 pM.

Anti-Mouse CD70 Rabbit Recombinant Antibody, PBS Only

CD70 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98212-1-PBS

产品说明书

CloneNo. 241553F2

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC

别名

241553F2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98212-1-PBS targets CD70 in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
经测试反应性 mouse
免疫原 CD70 fusion protein Eg1294 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 CD70 antigen
别名 241553F2
计算分子量22 kDa
GenBank蛋白编号NM_011617.2
基因名称 Cd70
Gene ID (NCBI) 21948
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDO55237
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD70, also known as tumor necrosis factor ligand superfamily member 7 (TNFSF7) or CD27 ligand (CD27L), is a transmembrane protein that plays a significant role in the immune system. It is the unique ligand for CD27, a member of the tumor necrosis factor receptor (TNFR) family, and is transiently upregulated upon stimulation of immune cells. CD70 is expressed on lymphocytes and dendritic cells, and its expression can be regulated by activation signals received via toll-like receptors (TLRs), CD40, and the antigen receptor MHC II. It provides complex and not completely understood signaling for B cell development. CD70 is also expressed on various solid tumors and hematolymphoid malignancies, where it may contribute to a poor prognosis. (PMID: 34991665; 26213107; 26098609)