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验证数据展示

  • IF Staining of Jurkat using 66801-1-Ig (same clone as 66801-1-PBS)

    IF Staining of Jurkat using 66801-1-Ig (same clone as 66801-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed Jurkat cells using CCR6 antibody (66801-1-Ig, Clone: 1C11A9 ) at dilution of 1:800 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

    IHC staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66801-1-Ig (CCR6 antibody) at dilution of 1:500 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

    IHC staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66801-1-Ig (CCR6 antibody) at dilution of 1:500 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

  • IF Staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

    IF Staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using CCR6 antibody (66801-1-Ig, Clone: 1C11A9 ) at dilution of 1:800 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

CCR6 Monoclonal antibody, PBS Only

CCR6 Monoclonal Antibody for IHC, IF/ICC, IF-P, ELISA
Cat No. 66801-1-PBS

产品说明书

CloneNo. 1C11A9

宿主/亚型

Mouse / IgG2a

种属反应性

human

应用

IHC, IF/ICC, IF-P, ELISA

别名

1C11A9, BN 1, C C chemokine receptor type 6, C C CKR 6, C-C chemokine receptor type 6

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

66801-1-PBS targets CCR6 in IHC, IF/ICC, IF-P, ELISA applications and shows reactivity with human samples.

经测试应用 IHC, IF/ICC, IF-P, ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag24195

Product name: Recombinant human CCR6 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-47 aa of BC037960

Sequence: MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRL

种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 chemokine (C-C motif) receptor 6
别名 1C11A9, BN 1, C C chemokine receptor type 6, C C CKR 6, C-C chemokine receptor type 6
计算分子量 42 kDa
GenBank蛋白编号BC037960
基因名称 CCR6
Gene ID (NCBI) 1235
RRIDAB_2882144
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP51684
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CCR6, also known as CD196, is a C-C chemokine receptor that belongs to family A of G protein-coupled receptor superfamily. It is expressed in most B cells, memory T cells, and some subsets of dendritic cells (PMID: 17057190). CCR6 is a receptor for the C-C type chemokine CCL20 (PMID: 9169459). The ligand-receptor pair CCL20-CCR6 is responsible for the chemoattraction of immature dendritic cells, effector/memory T-cells, and B-cells and plays a role in skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and rheumatoid arthritis (PMID: 12948524). CCR6 polymorphism has been associated with rheumatoid arthritis susceptibility and CCR6 is involved in IL-17-driven autoimmunity in human diseases (PMID: 20453841).

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