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CCR6 Monoclonal antibody, PBS Only

CCR6 Monoclonal Antibody for IHC,IF,FC,ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human

Applications

IHC,IF,FC,ELISA

Conjugate

Unconjugated

CloneNo.

1C11A9

Cat No : 66801-1-PBS

Print datasheet

Synonyms

BN 1, C C chemokine receptor type 6, C C CKR 6, CC CKR 6, CCR 6, CCR6, CD196, Chemokine receptor like 3, CKR L3, CKR6, CKRL3, CMKBR6, DCR2, DRY 6, DRY6, G protein coupled receptor 29, GPR CY4, GPR29, GPRCY4, LARC receptor, STRL22

验证数据展示

  • IF Staining of Jurkat using 66801-1-Ig (same clone as 66801-1-PBS)

    IF Staining of Jurkat using 66801-1-Ig (same clone as 66801-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed Jurkat cells using CCR6 antibody (66801-1-Ig, Clone: 1C11A9 ) at dilution of 1:800 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

  • FC experiment of Jurkat using 66801-1-Ig (same clone as 66801-1-PBS)

    FC experiment of Jurkat using 66801-1-Ig (same clone as 66801-1-PBS)

    1X10^6 Jurkat cells were intracellularly stained with 0.4 ug Anti-Human CCR6 (66801-1-Ig, Clone:1C11A9) and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000 (red), or 0.4 ug Mouse IgG2a Isotype Control (66360-2-Ig, Clone: K11A1B2A2) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

    IHC staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66801-1-Ig (CCR6 antibody) at dilution of 1:500 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

    IHC staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66801-1-Ig (CCR6 antibody) at dilution of 1:500 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

  • IF Staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

    IF Staining of human tonsillitis using 66801-1-Ig (same clone as 66801-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using CCR6 antibody (66801-1-Ig, Clone: 1C11A9 ) at dilution of 1:800 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66801-1-PBS in a different storage buffer formulation.

产品信息

66801-1-PBS targets CCR6 in IF, FC, IHC, ELISA applications and shows reactivity with Human samples.

Tested Applications IHC,IF,FC,ELISA
Tested Reactivity Human
Immunogen CCR6 fusion protein Ag24195 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name chemokine (C-C motif) receptor 6
Synonyms BN 1, C C chemokine receptor type 6, C C CKR 6, CC CKR 6, CCR 6, CCR6, CD196, Chemokine receptor like 3, CKR L3, CKR6, CKRL3, CMKBR6, DCR2, DRY 6, DRY6, G protein coupled receptor 29, GPR CY4, GPR29, GPRCY4, LARC receptor, STRL22
Calculated Molecular Weight 42 kDa
GenBank Accession NumberBC037960
Gene Symbol CCR6
Gene ID (NCBI) 1235
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP51684
Storage Buffer PBS only
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

CCR6, also known CD196, is a C-C chemokine receptor that belongs to family A of G protein-coupled receptor superfamily. It is expressed on most B cells, memory T cells, and some subsets of dendritic cells (PMID: 17057190). CCR6 is a receptor for the C-C type chemokine CCL20 (PMID: 9169459). The ligand-receptor pair CCL20-CCR6 is responsible for the chemoattraction of immature dendritic cells, effector/memory T-cells and B-cells and plays a role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and rheumatoid arthritis (PMID: 12948524). CCR6 polymorphism has been associated with rheumatoid arthritis susceptibility and CCR6 is involved in IL-17-driven autoimmunity in human diseases (PMID: 20453841).