验证数据展示
产品信息
98464-1-PBS targets CCL11/Eotaxin in FC (Intra) applications and shows reactivity with mouse samples.
经测试应用 | FC (Intra) Application Description |
经测试反应性 | mouse |
免疫原 | CCL11/Eotaxin fusion protein Eg2400 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | chemokine (C-C motif) ligand 11 |
别名 | C-C motif chemokine 11, Ccl11, Eosinophil chemotactic protein, Eotaxin, Scya11 |
计算分子量 | 11kd |
GenBank蛋白编号 | NM_011330 |
基因名称 | Ccl11 |
Gene ID (NCBI) | 20292 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P48298 |
储存缓冲液 | PBS only, pH 7.3. |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CCL11 also named Eotaxin-1, was initially discovered as an eosinophil-specific chemoattractant. CCL11 plays a central role in both allergic and non-allergic inflammatory reactions by recruiting immune cells such as eosinophils,basophils and Th2 lymphocytes. CCL11 binds to the chemokine receptors CCR2, CCR3 and CCR5, with highest affinity to CCR3. High levels of CCL11 have been described in several chronic inflammatory diseases, such as allergic rhinitis, atopic dermatitis, asthma, gastrointestinal disease and rheumatoid arthritis.