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验证数据展示

  • WB analysis of mouse testis using 20780-1-AP (same clone as 20780-1-PBS)

    WB analysis of mouse testis using 20780-1-AP (same clone as 20780-1-PBS)

    mouse testis tissue were subjected to SDS PAGE followed by western blot with 20780-1-AP (C11orf70 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20780-1-PBS in a different storage buffer formulation.

  • IHC staining of human testis using 20780-1-AP (same clone as 20780-1-PBS)

    IHC staining of human testis using 20780-1-AP (same clone as 20780-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human testis using 20780-1-AP (C11orf70 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 20780-1-PBS in a different storage buffer formulation.

  • IHC staining of human testis using 20780-1-AP (same clone as 20780-1-PBS)

    IHC staining of human testis using 20780-1-AP (same clone as 20780-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human testis using 20780-1-AP (C11orf70 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 20780-1-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 20780-1-AP (same clone as 20780-1-PBS)

    IF Staining of HeLa using 20780-1-AP (same clone as 20780-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using C11orf70 antibody (20780-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 20780-1-PBS in a different storage buffer formulation.

C11orf70 Polyclonal antibody, PBS Only

C11orf70 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 20780-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

CFAP300, Cilia- and flagella-associated protein 300, CK070

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

20780-1-PBS targets C11orf70 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag14793

Product name: Recombinant human C11orf70 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-229 aa of BC006128

Sequence: MLGRIKAQAFGFDQTFQSYRKDDFVMAFFKDPNVIPNLKLLSDSSGQWIILGTEVKKIEAINVPCTQLSMSFFHRLYDEDIVRDSGHIVKCLDSFCDPFLISDELRRVLLVEDSEKYEIFSQPDREEFLFCLFKHLCLGGALCQYEDVISPYLETTKLIYKDLVSVRKNPQTKKIQITSSVFKVSAYDSAGMCYPSAKNHEQTFSYFIVDPIRRHLHVLYHCYGVGDMS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 chromosome 11 open reading frame 70
别名 CFAP300, Cilia- and flagella-associated protein 300, CK070
计算分子量 267 aa, 31 kDa
观测分子量 31 kDa
GenBank蛋白编号BC006128
基因名称 C11orf70
Gene ID (NCBI) 85016
RRIDAB_10755147
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9BRQ4
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The CFAP300 protein is an important member of the cilia- and flagella-associated protein family, localized in the basal body and axoneme structures of cellular cilia. It plays a central role in ciliary assembly and stability, primarily by participating in the transport and anchoring of pre-assembled complexes within the cytoplasm. Research indicates that mutations in the CFAP300 gene lead to structural and functional defects in cilia, which are closely associated with various human ciliopathies, such as primary ciliary dyskinesia, heterotaxy, and male infertility. Loss of its function disrupts intraflagellar transport, affecting key physiological processes including left-right axis determination during embryonic development and mucociliary clearance in the respiratory tract. Therefore, CFAP300 is a crucial protein molecule for understanding ciliary biology and the mechanisms of related diseases.

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