Anti-Human BST2 Rabbit Recombinant Antibody

BST2 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98305-2-RR

产品说明书

CloneNo. 250317H5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

CD317, Bone marrow stromal antigen 2, BST 2, BST-2, CD 317

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格价格库存


经过测试的应用

Positive FC detected inhuman PBMCs

推荐稀释比

应用推荐稀释比
Flow Cytometry (FC)FC : 0.25 ug per 10^6 cells in a 100 µl suspension
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98305-2-RR targets BST2 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 BST2 fusion protein Eg1961 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 bone marrow stromal cell antigen 2
别名 CD317, Bone marrow stromal antigen 2, BST 2, BST-2, CD 317
计算分子量 180 aa, 20 kDa
GenBank蛋白编号BC033873
基因名称 BST2
Gene ID (NCBI) 684
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ10589
储存缓冲液 PBS with 0.09% sodium azide, pH 7.3.
储存条件Store at 2 - 8°C. Stable for one year after shipment.

背景介绍

BST2, also named as CD317 and Tetherin, belongs to the tetherin family. It may be involved in the sorting of secreted proteins and it is involved in pre-B-cell growth. BST2 is an antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. BST2 may play a role in B-cell activation in rheumatoid arthritis. It is recently identified interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. BST2 is a plasma membrane proteins, tetherin inhibits virion particle release from infected cells. BST2 is effective against retroviruses and flavoviruses whilst IFITMs disrupt influenza and flavivirus infection. Observed MW of BST2 is 30-36 kDa (PMID: 19196977; 21237475).

实验方案

Product Specific Protocols
FC protocol for BST2 antibody 98305-2-RRDownload protocol
Standard Protocols
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